Eco Hvar - Pesticides and their adverse effects

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Pesticides and their adverse effects

Published in Poisons Beware

Scientific evidence of the dangers surrounding chemical pesticides commonly used on Hvar and other parts of Croatia.

Photo: Vivian Grisogono

Our listing is in alphabetical order and is divided into two parts: the first part names pesticides in common use in Croatia together with their active ingredients, Croatian approval status, and European approval status for their active ingredients. The second part lists the active ingredients by category: 1. insecticides, 2. synergist, 3. fungicides, 4. limacide (molluscicide), 5. rodenticides, 6. herbicides. For each substance we identify the following: the type of poison; known possible adverse effects; approval status in the European Union (EU) and Croatia; some of the commercial products containing the active substance; and the scientific and official sources of information regarding the active substance.

Note re authorizations of chemical pesticides: we believe that the separation of chemical poisons into 'plant protection products' and 'biocides' (see 'Pesticides, Laws and Permits' for more details) leads to confusion about which substances are and are not officially approved. More damagingly, it gives rise to situations where biocides which are banned as 'plant protection' products are used over fields and gardens with crops such as vines, olives, other fruits and vegetables, and so enter the food chain despite being banned. This happens regularly throughout Croatia because of the Pest Suppression Programme.

Approvals in the EU. To check the EU status of any 'plant protection' product, you should refer to the EU Pesticides Database. Each entry includes the latest legislation relating to the listed pesticides. The European Chemicals Agency (ECHA) records approvals of biocidal active substances and products. Its website is the primary source of information about the laws governing biocidal pesticides and their approval processes. You can check its list of substances which are approved, banned or under review on the ECHA website page: mouse over Information on chemicals' in the header; then click on 'Biocidal active substances', under 'BPR' in the submenu; click on 'biocidal active substances' under the heading 'Information on biocides'; click 'search' in the next field, and type the name of the substance in the box marked 'Substance name', click the 'search' button below right; the substance, if identified, will come up as a special listing at the bottom of the page. It will show one or more versions of the substance, giving various details, including approval status; to the right of the entry is a box linking to authorized products based on the active substance. Note: the names under which pesticide products are marketed in Croatia mostly do not appear on the EU listings. The EU and ECHA listings of approved substances do not always agree.

Approvals in Croatia. The Croatian Phytosanitary Institution - Fitosanitarni informacijski sustav (FIS) lists the 'plant protection' pesticides approved for use in the Republic of Croatia. It used to have a separate listing of products whose approval has been withdrawn, but that no longer exists in 2021. There are two further sources of information about pesticides in Croatia: 'Agroklub' i 'Agrobase Croatia'. Note: the three Croatian sources sometimes offer conflicting information about approved and banned pesticides.

The search page of the Croatian Ministry of Agriculture's Phytosanitary Information Institution (FIS), which carries the list of approved 'plant protection' pesticides in Croatia, is in English, but details of the pesticides come up in Croatian.

To use the search page, type in the name of the product in the box labelled Trade Name of 'Plant Protection Product'; if it is registered for use in Croatia, it will appear as a pop-up under the Trade Name box; there may be different varieties of the product using the same name, so you can click on the one you want to enter it into the Trade Name box; then click on the 'search' button at the bottom of the page (if you leave the general name in the box, any varieties will be shown when you have clicked on the search button); click on the product as shown under the search button to find all its details. If no product shows up from the search, it means it is not approved.

In 2016, the Croatian Ministry of Health (MIZ) issued a list of biocidal pesticides which were allowed to be released in the Croatian market up to September 1st 2015 (NN 15/2016, link in Croatian). The Ministry of Health still controls the register of biocidal pesticides (Registar biocidnih pripravaka - ožujak 2021) allowed in the Croatian market. Applications to be included in the Register of products which can be marketed in Croatia are made to the Minsitry of Health.

While residues of 'plant protection' products are allowed to some degree in the food chain, biocides are not (see our article 'Pesticides, Laws and Permits' for further details). The Ministry of Health's 2021 list of approved biocides includes products whose active ingredients are not approved by the ECHA, such as Neopitroid Premium, which contains the banned substance Esbiothrin, and Permex 22E, which contains Tetramethrin. (There is a warning in red letters at the very end of the document that in some cases inclusion in the list is invalid, but this can give rise to confusion.) Biocides are regularly sprayed over large areas of Croatia including land used for crop cultivation as part of the Pest Control Programme, giving rise to the risk that banned substances will enter the food chain (see our article 'Poisoning Paradise - a Wake-Up Call' for a description of the problems).

Note: in our text, DDD (which stands for 'Dezinfekcija, dezinsekcija, deratizacija') refers to the Croatian national Pest Control Programme, which is carried out continuously throughout the country.

Insects are vital in the natural chain. Photo: Vivian Grisogono

INSECTICIDES. - ECHA APPROVAL CODE PT18 (Insecticides, acaricides, products to control other arthropods)

ABAMECTIN (See Emamectin) Combination of Avermectin B1a & B1b, growth regulator, insecticide, miticide, nematicide, derived from soil bacterium Streptomyces avermitilis.

Possible adverse effects: extremely toxic to bees, birds; highly toxic to aquatic life: fish, invertebrates, plants, algae and sediment dwelling organisms; toxic to earthworms; highly toxic to humans through skin contact, inhalation or ingestion: can cause problems for reproduction, impairing male fertility; neurological damage including tremors and ataxia; respiratory failure; skin and eye irritation.

EU: Approved 01/05/2009 - 30/04/2022. ECHA: Approved PT18 01/07/2013 - 30/06/2023

Products: Vertimec 018EC, Vertimec Pro, Kraft 18EC ECHA-approved include BAYGON BAITS, Baygon Esca SLuna ® Privilege (fluopyram with trifloxystrobin);carafaggi, Raid baits, Raid Roach Bait, RAID Klopka za Žohare.

Croatia FIS: Vertimec O18EC approved 12/06/2006.- 31/12/2023; Vertimec Pro approved 18/05/2016.-30/04/2022. MIZ: Vertimec O18EC, Vertimec Pro not approved

Sources: - ECHA 2019. Abamectin Factsheet

- University of Hertfordshire: Pesticide Properties Database. 2021. Abamectin

- PubChem Open Chemistry Database. 2006, updated 2021. Abamectinnot approved

- University of California, Statewide Integrated Pest Management Program. Abamectin

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Vertimec 018EC and Kraft 18EC (10.05.2019, 19.06.2019)

ACETAMIPRID. Neonicotinoid

Possible adverse effects: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment; highly toxic to honeybees if mixed with piperonyl butoxide or propiconazole; harmful for populations of pollinating insects; harmful to birds and earthworms; dangerous for the environment; in humans: h Cuprablau Z Ultra not approvedarmful - toxic if swallowed; can be fatal if inhaled; skin irritant

EU: Approved 01/03/2018 - 28/02/2033.ECHA: Approved, PT18, 01/02/2020 - 31/01/2027.

Products: Mospilan 20SP (registration revoked 01.01.2016, re-registered 30.10.2015 to 30.04.2023), Mospilan 20SG (Croatian registration revoked 01/01/2012, re-authorized 07/10/2015 - 30/04/2023.), Acelan 20SP, Volley, Wizzaard, Macho 60FS. ECHA: no related products authorized

Croatia FIS: Mospilan 20SG approved 07/10/2015-30/04/2023. Mospilan 20SP approved 30/10/2015-30/04/2023. MIZ: Mospilan 20SG, Mospilan 20SP not approved

Sources: - Iwasa, T., Motoyama, N., Ambrose, J.T., Roe, R.M. 2004. Mechanism for the differential toxicity of neonicotinoid insecticides in the honey bee, Apis mellifera. Crop Protection 23: 371-378

- El Hassani, A. K., Dacher, M., Gary, V., Lambin, M., Gauthier, M., Armengaud, C. 2008. Effects of Sublethal Doses of Acetamiprid and Thiamethoxam on the Behavior of the Honeybee (Apis mellifera). Archives of Environmental Contamination and Toxicology. 54 (4) 653-661

- University of Hertfordshire: Pesticide Properties Database. 2021. Acetamiprid

- Cayman Chemical 2018. Safety Data Sheet: Acetamiprid

- PubChem Open Chemistry Database. 2005, updated 2021. Acetamiprid

USED ON HVAR: Mospilan used by vegetable-growers (see 'Starigrad Plain: Our Survey')

ALLETHRIN (d-Allethrin). Synthetic pyrethroid

Possible adverse effects: Very toxic to aquatic life, with long-lasting effects; toxic to honey-bees and earthworms; moderately toxic to birds; harmful to humans if swallowed or inhaled.

EU: Not approved. ECHA: Not approved, under evaluation in January 2020. Croatia FIS: not approved.

Products: Neopitroid Premium (with Permethrin and Piperonyl Butoxide) EU, ECHA, Croatia FIS: No approved products Neopitroid Premium not approved MIZ: Neopitroid Premium approved July 2011.

Sources:

- ECHA 2019. Substance information

- University of Hertfordshire: Pesticide Properties Database. 2021. Allethrin

USED ON HVAR: 2018. Neopitroid Premium was used for insect suppression in the Sućuraj area on July 3rd and August 11th 2018.

USED IN NORTHERN CROATIA: DDD programme, Neopitroid Premium was used, for instance, for aerial spraying in the Vukovar-Srijem County (2014) and Osijek-Baranja County (2019); fogging actions in Velika Gorica and Glina (2021).

ALPHA-CYPERMETHRIN (ALPHAMETHRIN). Synthetic pyrethroid.

Possible adverse effects: highly toxic to fish, most aquatic organisms and honeybees; extremely toxic to aquatic life with long-lasting effects; toxic to earthworms; possible human carcinogen; can cause organ damage, respiratory irritation, irreversible eye damage; serious water pollutant.

EU: not approved. ECHA: Approved, PT18, 01/07/2016 - 30/06/2026; 01/06/20-31/05/2030

Products: Fastac 10 EC, Neopitroid Alfa, Antec, Contest, Fedona, Littac, Tenopa. ECHA: no related products authorized as at 06/05/2019. 10 approved products (as at 23/03/2020) including Canasta 1.5SC, Fendona 1.5SC, Littac, Pamova 1.5SC, Cardamon &SC, DigrainAC, Inastro 6SC, Olimero 6SC

Croatia FIS/MIZ: Fastac 10EC, Fastac 10SC not approved FIS: Neopitroid Alfa not approved. MIZ: not approved as at 01/09/2021.

Sources: - ECHA 2019. Alpha-Cypermethrin Factsheet.

- ECHA (updated 15/08/2018) Alpha-cyoermethrin

- University of Hertfordshire: Pesticide Properties Database. 2021. Alpha-cypermethrin.

- El Okda, E-S., Abdel-Hamid, M. A-A., Hamdy, A.M. 2017. Immunological and genotoxic effects of occupational exposure to alpha-cypermethrin pesticide. International Journal of Occupational Medicine and Environmental Health. Vol 30 (4) 603-615.

- Bej, S., Mukherjee, D., Saha, N.C. 2015. Acute toxicity of alpha-cypermethrin to oligochaete worm, Branchiura sowerbyi (Beddard 1982) along with their behavioural responses. International Journal of Scientific Research. 1:12, 325- 326.

- Wast, N., Gupta, A.K., Prakash, M.M., Gaherwal, S. 2014. Toxic Effect of Alphamethrin 10 EC on Freshwater Fish, Poecilia reticulata (Peters, 1859). World Applied Sciences Journal 30 (6): 782-786.

- Kemabonta, K., Akinhanmi, F.O. 2013. Toxicological Effects of Chlorpyrifos, Dichlorvos and Alpha Cypermethrin on Adult Albino Mice, Mus Musculus. Production, Agriculture and Technology. 9 (2): 1-17.

- Sarikaya, R., 2009. Investigation of Acute Toxicity of Alpha-Cypermethrin on Adult Nile Tilapia (Oreochromos niloticus L.). Turkish Journal of Fisheries and Aquatic Sciences 9: 85-89

USED ON HVAR: Fastac EC is used against fruit fly, especially in olive groves, by many individual agriculturalists. (see 'Starigrad Plain: Our Survey')

AQUATAIN AMF. Silicone-based liquid larvicide (film over the surface of standing water causes pupae and larvae to suffocate)

Possible adverse effects: can damage non-target organisms which depend on the water surface for respiration and movement.

EU: European Commission exempted Aquatain from registration due to its mode of action.

Product description: Aquatain AMF (https://www.aquatain.com/Aquatain-AMF.html)

- Mbare, O., Lindsay, S.W., Fillinger, U. 2014. Aquatain® Mosquito Formulation (AMF) for the control of immature Anopheles gambiae sensu stricto and Anopheles arabiensis: dose-responses, persistence and sub-lethal effects. Parasites and Vectors 7:438

USED ON HVAR: DDD programme, 2017 Stari Grad region 9 litres, 23-25 May; Jelsa region 16 litres, 19-22 May 2017.

AVERMECTIN (see Abamectin)

AZAMETHIPHOS. Organophosphate, designed for use on target areas, not for spraying in the air; mainly used against flies in enclosed spaces, on horses, cattle, pigs and chickens.

Possible adverse effects: very toxic to aquatic life, with long-lasting effects; toxic to birds; acutely toxic to humans if swallowed or inhaled; can cause headache, weakness, nervousness, sweating, vomiting and difficulty swallowing. Exposure to extremely high levels may result in muscular twitching, eye pain, slurred speech, colic, hyper-salivation, heart complaints, breathing difficulties, convulsions and unconsciousness; also causes eye and skin irritation on contact

EU, not approved. ECHA: not approved.

Products: Muhomor, Salmosan, Alfacron 10, Alfacron Plus, Snip Fly Bait.

Croatia FIS: Muhomor not approved MIZ: Muhomor approved May 2014

Sources: - Pub Chem: 2021. Azamethiphos

- European Agency for the Evaluation of Medicinal Products 1999. Azamethiphos, Summary Report.

- Scottish Environment Protection Agency. Azamethiphos. Scottish Pollutant Release Directory.

- University of Hertfordshire. Azamethiphos. Veterinary Substances Database.

- Pesticides Action Network (PAN) Europe. 2006. What substances are banned and authorized in the EU market?

- Muhomor. 2017. Muhomor je insekticid topiv u vodi. Djelatna tvar: Azametifos u koncentraciji 10%. Genera, Jedna kompanija za Jedno zdravlje.

- ECHA (Updated 15/08/2018) Azamethiphos

USED ON HVAR against flies around rubbish bins and rubbish dumps 2017: Hvar Town and surrounds, (with Microfly) 20th June, (with Microfly) 13th July, 11th August heat-spray fogging in rubbish dumps; 28th September, 12th October fogging in rubbish dumps. Total quantity 40.5 kg; Stari Grad and surrounds, Muhomor 33 kg, Jelsa Council area 31.5 kg, May, July, August, September 2017. 2018: around Hvar Town, 25th July, 16th August, 4th September - total quantity 9 kg.

Organophosphates were not approved under the Insect Control Programme of Measures and Implementation Plans issued by the Split-Dalmatian County Public Health Institute in 2017 and 2018, yet Muhomor was used on Hvar in both years, also in 2019.

BACILLUS THURINGIENSIS ISRAELENSIS (Bti). Soil bacterium.

Possible adverse effects: can interfere with reproduction in birds; can cause eye and skin irritation in humans and animals; may disturb essential wetland organisms; long-term use perhaps causes loss of biodiversity in the environment.

EU: Approved 01/05/2009 - 30/04/2022. ECHA: Approved, PT18 01/10/2013 - 30/09/2023.

Products: Aquabac©, Teknar©, Bactimos©, and Vectobac©. Baturad WP. ECHA: 10 approved products as at 07.11.2019, including Aquabac, Bactimos, Vectobac, Culinex Tab Plus, Neudomick Stechmüchen Frei, Neudomick Stechmüchen Flüssing. Baturad was not included.

Croatia FIS: Baturad WP approved 03/12/2004.-31/12/2023. MIZ: Baturad not approved

Sources: - Washington State Department of Health. Mosquito Larvicide - Bti.

- Siegel, J.P., Shadduck, J.A. 1990. Mammalian Safety of Bacillus thuringiensis israelensis. in: de Barjac, H., Sutherland, D.J. eds, Bacterial Control of Mosquitoes and Blackflies. pub. Unwin Hymen, London, pp. 202- 2017

- Lacey, L.A., Merritt, R.W. c.2001. The Safety of Bacterial Microbial Agents Used for Control of Blackfly and Mosquito Control in Aquatic Environments. (PDF document. Authors affiliated to USA Yakima Agricultural Research Laboratory and Michigan State University respectively.)

- Poulin, B., Lefebre, G., Paz, L., 2010. Red flag for green spray: adverse trophic effects of Bti on breeding birds. Journal of Applied Ecology. Vol.47, Issue 4, 884-889.

- Maletz, S., Wollenweber, M., Kubiak, K., Müller, A., Schmitz, S., Maier, D., Hecker, M., Hollert, H.. 2015. Investigation of potential endocrine disrupting effects of mosquito larvicidal Bacillus thuringiensis israelensis (Bti) formulations. The science of the total environment. Vol.536, 729-738.

- Kastel, A., Allgeier, S., Bruhl, C. A. 2017. Decreasing Bacillus thuringiensis israelensis sensitivity of Chironomus riparius larvae with age indicates potential environmental risk for mosquito control. Scientific Reports 7: article 13565

USED ON HVAR: 2017: 22nd September, and 2018: 19th September, Baturad was used on 3 hectares of woodland around the Hvar Town region against the Pine Processionary Moth caterpillars, quantity 600 litres each time.

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Baturad WP (14.06.2019)

2019: Baturad (or Decis or Imidan or Rogor) recommended by a well-respected Hvar olive oil producer, to be used in May and June against olive moth (prays oleae, Croatian: maslinin moljac)

CARBARYL. Carbamate

Possible adverse effects: Highly toxic to mammals, aquatic invertebrates, aquatic crustaceans, bees, earthworms. Can be fatal in humans; possible carcinogen and endocrine disruptor; possibly damaging for reproduction and development; can cause cholinesterase inhibition, blurred vision, tears, headaches, memory loss, rhinorrhoea (discharge of thin nasal mucus), salivation; sweating, muscle weakness, abdominal cramps, nausea, vomiting, diarrhoea; tremors, cyanosis, convulsions and skin irritation.

EU, ECHA: Not approved

Product: Sevin. Combined with limacide Metaldehyde in Lily Miller Slug, Snail and Insect Killer Bait, and for Ortho Bug-Geta Plus.

Croatia FIS/MIZ: Sevin not approved

Sources: - University of Hertfordshire PPDB, updated 2021. Carbaryl.

- PubChem Open Chemistry Database. 2005, updated 2021. Carbaryl.

- U.S. Environmental Protection Agency. 2016. Carbaryl Factsheet.

WAS USED LONG-TERM IN CROATIA, especially for fruit thinning, applied two to three weeks after full flowering of the trees. (Refs: Radivojević et al. 2011. Effect of chemical and hand thinning young apple tree on yield and fruit quality. Proceedings, 46th Croatian and 6th International Symposium on Agriculture, Opatija Croatia, pp 1044-1047. Croatian Agriculture Ministry, article in Croatian). However, it is no longer authorized for this use in Croatia.

CHLORPYRIFOS. Organophosphate.

Possible adverse effects: highly toxic to honeybees, birds, fish, aquatic organisms; moderately toxic to earthworms, algae and aquatic plants; in humans can cause nausea, dizziness, confusion, and respiratory paralysis and death; causes neurodevelopmental defects in children; can harm mother and foetus during pregnancy; can cause acute muscle paralysis and weakness, also breathing difficulties, depression, and double vision in humans, dogs and cats; overexposure can cause weakness, ataxia (uncoordinated movements), proprioceptive dysfunctions (disturbed awareness of posture and movements), particularly of the hind legs, and paralysis in animals, including dogs and cats.

EU / ECHA: not approved.

Products: Pyrinex 48 EC, Pyrinex 250 CS, Dursban E48, Nufos

Croatia FIS/MIZ: Pyrinex 48 EC was finally banned in Croatia on 31/01/2019,; 16/02/2020, registration was withdrawn from all chlorpyrifos products, including Pyrinex 250 CS, Dursban E48, Nufos, with a final sell-by date of 16/03/2020, final use-by date 16/04/2020.

Sources: - Toxnet (Toxicology Data Network) 1983, updated 2015. Chlorpyrifos.

- United States Environmental Protection Agency 2016. Revised Human Health Risk Assessment on Chlorpyrifos.

- United Kingdom Health and Safety Executive (HSE) 2016. Changes to Authorisations for Products Containing Chlorpyrifos. (Use restricted to spraying brassica seedlings only, all existing stocks of chlorpyrifos to be destroyed)

- Eng, M.L., Stutchbury, B.J.M., Morrissey, C.A. 2017. Imidacloprid and chlorpyrifos insecticides impair migratory ability in a seed-eating songbird. Scientific Reports, 7., article no. 15176.

- Junquera, P. article updated 2017. CHLORPYRIFOS: SAFETY SUMMARY for VETERINARY USE in DOGS, CATS, HORSES, CATTLE, SHEEP, GOATS, SWINE and POULTRY. Poisoning, intoxication, overdose, antidote. Parasitipedia.net

- United States Court of Appeals for the Ninth Circuit, 2018. Lulac (11 Petitioners, including Pesticide Action Network (PANNA), Farmworker Justice GreenLatinos, Learning Disabilities Association of America, Farmworkers Association of Florida) v. Wheeler (for U.S. Environmental Protection Agency) EPA ordered to revoke all tolerances and cancel all registrations for chlorpyrifos within 60 days: Chlorpyrifos banned in the United States.

- University of Hertfordshire Pesticide Properties Database. updated August 2021. Chlorpyrifos.

- Health and Environment Alliance (HEAL) August 2018. Chlorpyrifos factsheet (with 40 references)

USED ON HVAR: 2016, Pyrinex 48 EC used on bushes and trees in Jelsa's public park preventively against aphids

CYPERMETHRIN. Synthetic pyrethroid.

Possible adverse effects: - very toxic to cats, bees, aquatic insects and fish, highly toxic to aquatic life with long-lasting effects; toxic to a lesser degree to birds.; in humans, classified as a possible cause of cancer; can cause organ damage, skin numbness or burning, respiratory irritation, loss of bladder control, vomiting, loss of co-ordination, coma, seizures, and (rarely) death.

EU: Permit 01/03/2006 - 31/10/2021. (Cypermethrin was re-approved in August 2018, subject to stringent conditions.) ECHA: Approved, PT18, 01/06/2020 - 31/05/2030

Products:Neo Alfa, Cythrin Max 250EC10E, Cipex, Microfly, Cymina Ultra, Cymina 10, Ammo, Cymbush, Demon, Raid Ant Killer, Hot-Shot Fogger, Raid Wasp and Hornet Killer. ECHA: no insecticidal products approved as at 01/09/2021, (although Cypermethrin was authorized for many wood preservative products, code PT08.)

Croatia FIS: Cythrin MAX 250EC approved 23/06/2015 -31/10/2021 Cymina Aqua, Cymina 10, Cymina Ultra, Cymina Plus, Cipex, Microfly not approved

MIZ: Neo Alfa approved 16/01/2018. Cymina 10 approved February 2011. Cymina Ultra approved February 2011. Cymina Plus, Cipex10E, Cythrin Max, Microfly not approved. ECHA: Neo Alfa not approved

Sources: - ECHA 2019. Cypermethrin Factsheet.

- ECHA (updated 15/08/2018) Cypermethrin

-PARASITIPEDIA.net. updated 2017. CYPERMETHRIN, safety summary for veterinary use.

-U.S. Environmental Protection Agency Office of Pesticide Programs. 2016. Chemicals Evaluated for Carcinogenic Potential. Annual Cancer Report.

-Aggarwal, P., Jamshed, N., Ekka, M., Imran A. 2015. Suicidal poisoning with cypermethrin: A clinical dilemma in the emergency department. Journal of Emergencies, Trauma and Shock. 8:2 123-125.

-TOXNET Toxicology Data Network (U.S.National Library of Medicine). 1986, updated 2012. Cypermethrin.

-PubChem Open Chemistry Database. 2021. Cypermethrin.

-Extension Toxicology Network, (Extoxnet). 1993. Pesticide Information profile: Cypermethrin. (Pesticide Information Project, Cornell University)

USED ON HVAR, DDD insect suppression programme: 2017: Hvar Town region, total quantity of Microfly used: 14 kg. Total quantity of Cipex used: 13 litres. 2017. Stari Grad Cipex total, 8 litres, Microfly 7 kg; Jelsa, Cipex 10 litres, Microfly 5 kg. 2018: Hvar Town region, Cipex total quantity 13 litres; Microfly 10.5L. Stari Grad region: Cipex 2L, Microfly 3L, Jelsa Council area Microfly 4 litres, Cipex 3 litres

2019, 2020 Microfly used for insect suppression (DDD programme) on Hvar.

2019: Cythrin Max 250EC recommended by a well-respected olive oil producer: Caythrin Max 250EC to be used in May against olive moth (prays oleae, Croatian: maslinin moljac)

2021: Neo Alfa used for insect suppression (DDD programme) on Hvar, according to the initial statement from DDD firm Ekocijan, but they stated later that the substance used was Neopitroid Alfa.

DELTAMETHRIN. Synthetic pyrethroid.

Possible adverse effects: Toxic to bees; highly toxic to cats; extremely toxic to aquatic life, with long-lasting effects; toxic to fish; also to aquatic herbivorous insects, causing increased algae; in humans can cause ataxia, convulsions leading to muscle fibrillation and paralysis, dermatitis, oedema, diarrhoea, dyspnoea, headache, hepatic microsomal enzyme induction, irritability, peripheral vascular collapse, rhinorrhoea, serum alkaline phosphatase elevation, tinnitus, tremors, vomiting and death due to respiratory failure. Possible allergic reactions: anaphylaxis, bronchospasm, eosinophilia, fever, hypersensitivity pneumonia, pallor, pollinosis, sweating, sudden swelling of the face, eyelids, lips and mucous membranes, and tachycardia.

EU: Approved: 01/11/2003 - 31/10/2021. ECHA: Approved, PT18, 01/10/2013 - 30/09/2023.

Products: Butoflin, Crackdown, Decis 2.5 EC, Decis 100 EC, Decis Trap, Scatto, Rotor Super, Poleci, Poleci Plus, Raid Max Bug Killer, Raid Max Spider, Scorpion Killer. Eco Trap.

Croatia FIS: Scatto approved 12/07/2016 -31/10/2021; Rotor Super approved 10/08/2016-31/10/2021; Poleci approved 15/01/2014-14/01/2024; Poleci Plus approved 11/05/2016-31/10/2021. Decis 100EC approved 18/03/2016 - 31/10/2021. Decis trap approved 23/09/2015 - 31/10/2021 . Decis 1,25EC, Decis 6,25EC, Eco Trap not approved, listed as having lost its authorization in 2011.) MIZ: Decis 1,25EC, Decis 6,25EC,Decis Trap, Poleci, Poleci Plus, Scatto, Rotor Super not approved

Sources: - ECHA 2019. Deltamethrin Factsheet.

- ECHA (updated 15/08/2018) Deltamethrin

- PubChem, Open Chemistry Database. 2021. Deltamethrin.

- Dai, P-L., Wang, Q., Sun, J-H., Liu, F., Wang, X., Wu, Y-Y., Z. T. 2009. Effects of sublethal concentrations of bifenthrin and deltamethrin on fecundity, grogod.wth, and development of the honeybee Apis mellifera ligustica. Environmental Toxicology. 29-3, 644-649

- Extension Toxicology Network (Extoxnet) 1995. Deltamethrin. (Pesticide Information Project, Cornell University)

- Parasitipedia.net. Deltamethrin: Safety Summary for Veterinary Use

ON HVAR: Deltamethrin was on the list of pesticides recommended for use around Hvar Town, Stari Grad and the Jelsa Council area, under the Programme issued by the Split-Dalmatian County Public Health Institute for 2017 and 2018.

2018: Croatian Agriculture-Forestry Advisory Section for the Split-Dalmatian county recommended Deltamethrin and the products Decis 100EC, Decis 2.5EC, Scatto, Rotor Super, and Poleci Plus were recommended for use on Hvar and in other olive-growing areas against fruit-flies in July 2018.

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Scatto and Poleci Plus (14.06.2019, 13.09.2019, 27.09.2019); Decis 2.5 EC, Decis 100 EC, Rotor Super (1 4 .06.2019, 19.06.2019, 13.09.2019, 27.09.2019); Eco Trap (13.09.2019)

2019: Decis (or Imidan, or Baturad or Rogor) recommended by a well-respected Hvar olive oil producer, to be used in May and June against olive moth (prays oleae, Croatian: maslinin moljac); Decis (or Imidan or Rogor, or Rogor with the attractant Buminal, or Success Bait, or Eko-Trap) in July, August, September and October against olive fruit fly (bactrocera oleae, Croatian: maslinova muha)

DIFLUBENZURON. Benzamide insecticide, Insect Growth Regulator (Disruptor) (IGR).

Possible adverse effects: Highly toxic to freshwater and marine invertebrates; moderately toxic to fish and earthworms; slightly toxic to birds; affected haemoglobin in animal studies; can cause breathing difficulties in humans; direct contact can be harmful to skin and eyes; metabolites are possible human carcinogens.

EU: not approved as from 31/12/2020. ECHA: Approved, PT18, 01/02/2015 - 31/12/2025.

Products: Dimilin, Flubex

Croatia FIS: Dimilin SC48 approved 26/02/1999-31/12/2023. Flubex not approved MIZ:Dimilin SC48 approved January 2010, Dimilin GR2, TB2, SC15 approved August 2009. Flubex not approved

Sources: - United States Environmental Protection Agency 1997. Reregistration Eligibility Decision (R.E.D.): Diflubenzuron.

- PubChem Open Chemistry Database, updated 2021. Diflubenzuron.

- University of Hertfordshire Pesticide Properties Database, updated 2021. Diflubenzuron.

- ECHA (updated 15/08/2018) Diflubenzuron

USED ON HVAR: DDD programme, for larvicidal actions, Flubex, 2016: Hvar Town and surrounds, May and October 2016. Stari Grad and surrounds, April and October 2016; Jelsa Council area, April-May and October 2016. 2017: Jelsa Council area: Dimilin used for larvicide, rainwater drains & septic tanks, June & July 2017. 2018: Dimilin used in the Hvar Town region, 13th June, 3rd July, 5.5 kg. Dimilin used in Vrboska on the road to Soline bathing beach (at the request of residents), in Jelsa around the Park and in the rainwater drains in the centre of Jelsa, 13th June & 25th July 2018, 5 kg.

2019, 2020: Dimilin used in the Jelsa Council region

DIMETHOATE. Organophosphate.

Possible adverse effects. Very toxic to bees and aquatic organisms; possibly toxic to wildlife, including birds, and livestock: possible endocrine disruptor; in humans: can cause unconsciousness and death; possible human carcinogen (USEPA); inhalation, swallowing or excess skin contact can cause breathing difficulties, headache, dizziness, tiredness, slurred speech, blurred vision, a lack of coordination, sweating, slow or rapid heart beat, convulsions, incontinence; when swallowed, can also cause vomiting, diarrhoea, abdominal pain, faecal incontinence; long-term exposure may lead to impaired memory, depression, irritability, confusion and insomnia.

EU / ECHA: not approved

Products: Phosphamide, Rogor 40, Calinogor, Chromogor, Cygon, Perfekthion, Fosfamid 40, Aadimethoal.

Croatia FIS/MIZ: Calinogor, Fosfamid 40, Aadimethoal, Rogor 40, Chromogor, Perfekthion not approved. .

Sources: - World Health Organisation 1989. International Programme on Chemical Safety: Environmental Health Criteria for Dimethoate.

- Extension Toxicology Network (Extoxnet) 1993. Dimethoate.

- Scottish Environment Protection Agency. Dimethoate.

- PubChem Open Chemistry Database, updated 2021. Dimethoate. (Pesticide Information Project, Cornell University)

- University of Hertfordshire 2021. Pesticide Properties Database: Dimethoate.

USED ON HVAR: Rogor is used by farmers cultivating olives and other crops (see 'Starigrad Plain: Our Survey')

Dimethoate and the products Calinogor, Chromogor, Perfekthion, Rogor 40 were recommended for use on Hvar and in other olive-growing areas against fruit-flies by the Croatian Agriculture-Forestry Advisory Section for the Split-Dalmatian County, in July 2018.

2019: Rogor, also in combination with the attractant Buminal, recommended by a well-respected Hvar olive oil producer for use variously against olive moth (prays oleae, Croatian: maslinin moljac), olive fruit fly (bactrocera oleae, Croatian: maslinova muha), leopard moth (Zeuzera pyrina, Croatian: granotoč) and weevils (otiorhyncus, Croatian: Skorovača) in May, June, July, August, and September; Rogor (or Baturad) to be used in May against olive psyllid (euphyllura olivina, Croatian maslinova buha)

EMAMECTIN BENZOATE. Semisynthetic derivative of avermectin.

Possible adverse effects: Highly toxic to bees, birds, aquatic life, aquatic environment, algae; in humans: highly toxic through swallowing, inhalation and skin contact; can cause organ damage, serious eye irritation or damage; muscle tremors, muscle incoordination, vomiting, pulmonary oedema, unconsciousness; skin allergies.

EU: Approved 01/05/2014 - 30/04/2024. ECHA: not approved

Products: Revive, Affirm Opti, Proclaim.

Croatia FIS: Revive II authorized 19/03/2019 - 30/04/2025; Affirm Opti approved 26/03/2018.-30/04/2025. Proclaim not approved .MIZ: Affirm Opti, Revive II, Proclaim not approved

Sources: - United States Environmental Protection Agency. 2014. Emamectin Benzoate 4.0% Tree Injection, Label Amendment.

- PubChem Open Chemistry Database 2021. Emamectin

- University of Hertfordshire, Pesticide Properties Database 2021. Emamectin benzoate

- EU National Assessment, Evaluator FRANCE. 2018. Revive, Registration Report

- Cornell Cooperative Extension, Pesticide Management Education Program 2000. Emamectin Benzoate - Registration of Proclaim Insecticide 3/00.

USED ON HVAR Affirm used by individuals cultivating vines, olives, etc. (see 'Starigrad Plain: Our Survey')

2019, 2021: Jelsa local Council: Revive used on palm trees in Jelsa Park 12.04.2019. and 09/09/2021.

IMIDACLOPRID. Neonicotinoid.

Possible adverse effects: very toxic to bees, birds, also aquatic life and aquatic environments, with long-lasting effects; can affect reproduction and development in humans; possibly associated with autism spectrum disorder; moderately toxic to mammals, fish and earthworms; persists in soil.

EU: not approved as from 01/01/2020.. ECHA: Approved, PT18, 01/07/2013 - 30/06/2023.

Products: Quickbait (imidacloprid with tricosene), Admire, Advantage, Kohinor, Merit, Confidor, Hachikusan, Premise, Prothor, Winner

Croatia FIS: Quick Bayt not approved MIZ: Quick Bayt approved August 2009

Sources:

- Willis Chan, D., Raine, N.E. 2021. Population decline in a ground-nesting solitary squash bee (Eucera pruinosa) following exposure to a neonicotinoid insecticide treated crop (Cucurbita pepo). Scientific Reports 11, 4241 (2021). 74 references

- ECHA 2019. Imidacloprid Factsheet.

- PubChem Open Chemistry Database 2021. Imidacloprid. (Pesticide Information Project, Cornell University)

- University of Hertfordshire, Pesticides Properties Database. 2021. Imidacloprid.

- Baines, D., Wilton, E., Pawluk, A., de Gorter, M., Chomistek, N. 2017. Neonicotinoids act like endocrine disrupting chemicals in newly-emerged bees and winter bees. Scientific Reports 7: article number 10979

- Eng, M.L., Stutchbury, B.J.M., Morrissey, C.A. 2017. Imidacloprid and chlorpyrifos insecticides impair migratory ability in a seed-eating songbird. Scientific Reports, 7., article no. 15176.

- Pisa, L.W., Amaral-Rogers, V., Belzunces, L.P., Bonmatin, J.M., Downs, C.A., Goulson, D., Kreutzweiser, D.P., Krupke, C., Liess, M., McField, M., Morrissey, C.A., Noome, D.A., Settele, J., Simon-Delso, N., Stark, J.D., Van der Sluijs, J.P., Van Dyck, H., Wiemers, M. 2015. Effects of neonicotinoids and fipronil on non-target invertebrates. Environmental Science and Pollution Research, 22: 1: 68-102.

- Zhang, E., Nieh, J.C. 2015. The neonicotinoid imidacloprid impairs honey bee aversive learning of simulated predation. Journal of Experimental Biology, 218: 3199-3205

- Keil, A.P., Daniels, J.L., Hertz-Picciotto, I. 2014. Autism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: the CHARGE (Childhood Autism Risks from genetics and Environment) case-controlled study. Environmental Health, 13:3

USED ON HVAR: DDD programme, Quick Bayt® (imidacloprid with Tricosene) used on rubbish tips. 2018: Hvar Town region, July 3rd, 2 kg.; Stari Grad region, 3rd July, 25th July, 15th August, 6th September 2018, 2kg.

2017: Quick Bayt insecticde was used in the Sućuraj region, with thiamethoxam incorrectly listed as its active ingredient in the report to the Sućuraj council (certificate / potvrda 52177, dated 04/06/2017)

2020: Quick Bayt used around the Jelsa Council region (DDD programme)

PERMETHRIN. Synthetic pyrethroid.

Possible adverse effects: highly toxic to bees, sea organisms, fish; poisonous to cats, also other animals; in humans: classified as a potential carcinogen; linked to Non-Hodgkin Lymphoma; can cause neurological damage, also problems in the immune and endocrine systems.

EU: not approved. ECHA: approved, PT18, 01/05/2016 - 30/04/2026

Products: Permex 22E (withTetramethrin & Piperonyl Butoxide); Neopitroid Premium (with D-Allethrin and Piperonyl Butoxide); household fly-killer sprays such as Sanmex Fly and Wasp Killer; Raid formula 277 insect killer.

Croatia FIS: Permex 22E and Neopitroid Premium not approved. MIZ: Permex 22E approved April 2012. Neopitroid Premium approved July 2011.

You can find a list of Permethrin products on the 'Scorecard' Pollution Information Site.

Sources: - ECHA 2019. Permethrin Factsheet.

- ECHA (updated 15/08/2018) Permethrin

- Alavanja, M.C.R., Hoffmann, J.N., Lynch, C.F., Hines, C.J., Barry, K. H., Barker, J., Buckman, D.W., Thomas, K., Sandler, D. P., Hoppin, J.A., Koutros, S., Andreotti, G., Lubin, J.H., Blair, A., Beane Freeman, L.E. 2014. Non-Hodgkin Lymphoma Risk and Insecticide, Fungicide and Fumigant Use in the Agricultural Health Study. PLoS One (US National Library of Medicine, National Institutes of Health) 9 (10): e109332.

- U.S. Environmental Protection Agency. August 2009. Permethrin Facts.

- Hoffmann, M., Meléndez, J.L., Ruhman, M.A., 2008. Risks of Permethrin Use to the Federally Threatened California Red-legged Frog (Rana aurora draytonii) and Bay Checkerspot Butterfly (Euphydryas editha bayensis), and the Federally Endangered California Clapper Rail (Rallus longirostris obsoletus), Salt Marsh Harvest Mouse (Reithrodontomys raviventris), and San Francisco Garter Snake (Thamnophis sirtalis tetrataenia). Environmental Fate and Effects Division Office of Pesticide Programs, Washington, D.C. 20460

- U.S. Environmental Protection Agency. 2007. Permethrin & Resmethrin (Pyrethroids), Toxicity and Exposure Assessment for Children's Health. TEACH Chemical summary.

-World Health Organization. 2006. "International Program on Chemical Safety, Environmental Health Criteria 92: Permethrin."

- U.S. Environmental Protection Agency. 2006. "Reregistration Eligibility Decision (RED) for Permethrin."

- U.S. Centers for Disease Control (ATSDR). 2003. "Toxicological Profile for Pyrethrins and Pyrethroids."

- U.S. Environmental Protection Agency. 2002. "TRI Explorer: Providing Access to EPA's Toxic Release Inventory Data."

- International Cat Care. Permethrin Poisoning in Cats.

USED ON HVAR: DDD programme, for adult insect suppression: 2016: Permex 22E- Hvar Town and its surrounds, June, July x2, August, October; Stari Grad and its environs, June, July, August; Jelsa Council area, July x2, August 2016. 2017: Hvar Town and surrounds Permex 22E 25th May, 20th June; 13th July; 11th August, 28th September, 12th October. Permex 22E total: 22 litres; Stari Grad and surrounds 17-18th May, 14th July, 11th August, 26th September, total 10 litres; Jelsa Council region, 12th July, 10th August, 27th September 2017, 9 litres. 2018: Hvar Town region, 24th July 2018, quantity 3 kg; Stari Grad region, 26th July, 15th August, 6th September, 3L; Jelsa region, 25th July, 14th August, 5th September 2018, 4L. 2019, 2020, Permex22E used in the insect suppression fogging programme on Hvar (Hvar Town, Stari Grad, Jelsa).

2018. Neopitroid Premium was used for insect suppression in the Sućuraj area on July 3rd and August 11th 2018.

ON HVAR 2021: A chemical analysis by the Kudzu Science laboratory of a hair sample submitted in February revealed the presence of a significant quantity of permethrin in a 72-year-old resident of Pitve.

PHENOTHRIN, d-PHENOTHRIN. Synthetic pyrethroid

Possible adverse effects: Highly toxic to cats, bees and aquatic organisms; in humans, can cause dizziness, salivation, headache, fatigue, diarrhoea, irritability to sound and touch.

EU, ECHA: not approved (a parallel but distinct substance, IR-trans phenothrin, was given conditional approval in an Assessment Report under European Commission Directive 98/8/EC in 2013., ECHA, PT18, 01/09/2015 - 31/08/2025)

Products: Sumithrin, Raid, Enforcer Flea Killer, Enforcer BedBug spray, Enforcer Flying Insect Killer, Enforcer Wasp and Hornet Killer, Ortho Max Flying Insect Killer, Anvil.

Sources: - Parasitipedia. 2017. Phenothrin: safety summary for veterinary use.

- US EPA. 2008. Reregistration Eligibility Decision for d-Phenothrin.

- WHO/FAO 1994. d-Phenothrin. WHO/FAO Data Sheet on Pesticides no.85.

- Cox, C. 2003. Sumithrin (d-Phenothrin). Insecticide Factsheet. Journal of Pesticide Reform. 23 / 2, 10- 14.

ON HVAR: d-Phenothrin was on the list of pesticides recommended for use around Hvar Town, Stari Grad and the Jelsa Council area, under the Programme issued by the Split-Dalmatian County Public Health Institute for 2017.

PHOSMET. Organophosphate.

Possible adverse effects: highly toxic to aquatic life and environment; highly toxic to honeybees; in humans can be fatal if inhaled; if swallowed, causes stomach pain, diarrhoea, nausea, sickness; can cause organ damage, eye irritation; possibly causes fetal damage or disrupts fertility; can cause swelling, itchiness, raised skin temperature if absorbed through the skin; can be toxic to birds, earthworms, cats and dogs.

EU: 01/10/2017 - 31/07/2022 ECHA: not approved

Products: Imidan 50 WG, Imidan 50WP.

Croatia FIS: Imidan WG approved 29/09/2015-31/07/2022. Imidan 50WP not approved MIZ: Imidan 50WG, Imidan 50WP not approved

Sources: - Ultra Scientific Inc. Phosmet (Imidan) Safety Data Sheet.

- Extension Toxicology Network (Extoxnet) 1993. Phosmet. (Pesticide Information Project, Cornell University)

- United States Environmental Protection Agency. 2001. Pesticides: Reregistration. Phosmet IRED facts. (safer alternatives available)

- PubChem Open Chemistry Database: 2021. Phosmet (Imidan, Imidathion)

- University of Hertfordshire, Pesticide Properties Database, 2021: Phosmet.

2018. The Croatian Agriculture-Forestry Advisory Section for the Split-Dalmatian County recommended the Phosmet product Imidan for use on Hvar and in other olive-growing areas against fruit-flies in July 2018.

2019. Imidan (or - variously - Decis or Baturad or Rogor) recommended by a well-respected Hvar olive oil producer for use in May, June, against olive moth (prays oleae, Croatian: maslinin moljac); Imidan (or Decis or Rogor or Rogor with Buminal or Success Bait or Eko-Trap) recommended to be used in July, August, September and October against olive fruit fly (bactrocera oleae, Croatian: maslinova muha)

PYRIPROXYFEN Insect growth regulator (IGR). Aromatic ether, member of pyridines (substance group unclassified)

Possible adverse effects: Toxic to fish and aquatic invertebrates; Very toxic to aquatic life with long-lasting effects; moderately toxic to bees, earthworms; in humans: harmful if absorbed through the skin, or swallowed; causes eye irritation; possibly affects male fertility; possible endocrine disruptor, may have an estrogenic effect; possible liver and blood toxicant

EU: approved 01/08/2020 - 31/07/2035. ECHA: approved PT18 01/02/2015 - 31/01/2025.

Products: Pyxal, Sumilan, Proxilar compresse, Tigrex compresse.

Croatia FIS/ MIZ: Pyxal not approved

Sources: - PubChem 2021. Pyriproxyfen (compound)

- EFSA. 2020. Pyriproxyfen

- Shahid, A., Zaidi, S.D., Akbar, H., Saeed, S. 2019. An investigation on some toxic effects of pyriproxyfen in adult male mice. Iran Journal of Basic Medical Sciences 22 (9) 997 - 1003. 48 references

- Pesticide Properties Database. 2021. Pyriproxyfen.

- US Environmental Protection Agency. 2012. Label amendments for Pyriproxyfen Insect Growth Regulator.

ON HVAR: 2019: Pyxal recommended by a well-respected Hvar olive oil producer for use in May against scale insects (coccoidea, Croatian: štitašte uši)

RESMETHRIN. Synthetic pyrethroid.

Possible adverse effects: potentially harmful to humans: endocrine disruptor, neurotoxic, eye and skin irritant, possible thyroid toxicity; possible human carcinogen; highly toxic to fish and aquatic invertebrates; moderately toxic to birds;

EU, ECHA: not approved. [Banned in the United States since 2015.]

Products, Trade names: Chrysron, Crossfire, Raid Flying Insect Killer.

Sources: - PubChem Open Chemistry Database. 2021. Resmethrin.

- US EPA. 2011. Permethrin, Resmethrin, d-Phenothrin (Sumithrin®): Synthetic Pyrethroids for Mosquito Control.

- University of Hertfordshire, Pesticide Properties Database 2021. Resmethrin.

ON HVAR: Resmethrin was on the list of pesticides recommended for use around Hvar Town, Stari Grad and the Jelsa Council area, under the Programme issued by the Split-Dalmatian County Public Health Institute for 2017.

SPINOSAD, combination of Spinosyn A and Spinosyn D, derived from naturally occurring soil fungi (naturalyte)

Possible adverse effects: Highly toxic to aquatic organisms, with long-lasting effects; highly toxic to bees; toxic to fish and earthworms; in humans can cause allergic reactions and eye irritation.

EU: Approved 01/02/2007 - 30/04/2022. ECHA: Approved, PT18, 01/11/2012 - 31/10/2022.

Products: Laser, Success Bait.

Croatia FIS: Laser approved 20/03/2002-31/12/2023; Success Bait approved 11/01/2005-11/12/2023. MIZ: Laser, Success Bait not approved

Sources: - ECHA 2019. Spinosad Factsheet.

- University of Hertfordshire Pesticide Properties DataBase. 2021. Spinosad.

- PubChem Database 2021 Spinosad

- Syracuse Environmental Research Associates, Inc. 2016. Spinosad: Human Health and Ecological Risk Assessment. SERA TR-056-16-03b

- United States Environmental Protection Agency. 2009. EFED Risk Assessment for the Proposed IR-4 Use of the Spinosad product Entrust® on Pomegranate and Dates

ON HVAR: Laser used by individuals, especially on vines (see 'Starigrad Plain: Our Survey')

TETRAMETHRIN. Synthetic pyrethroid.

Possible adverse effects: potential human carcinogen, also can cause dizziness, breathing difficulties, coughing, eye irritation, gastrointestinal upset, blisters and skin rashes; extremely toxic to bees and aquatic organisms, including fish and aquatic invertebrates.

EU / ECHA: not approved:

Products: Permex 22E (with Permethrin & Piperonyl Butoxide); Cymina Plus (with Cypermethrin), Cymina Ultra (with Cypermethrin); Household insect-killing sprays such as Sanmex Fly and Wasp Killer.; Bonide Wasp and Hornet Killer, Enforcer Flea Spray, Hi-Yield Wasp and Hornet Spray, Ortho MAX Flying Insect Killer, Raid Flea Killer, Raid Flying Insect Killer.

Croatia FIS: Permex 22E, Cymina Plus, Cymina Ultra not approved MIZ: Permex 22E approved April 2012. Cymina Ultra approved February 2011.Cymina Plus not approved

Sources: - ECHA 2019. Tetramethrin Factsheet.

- U.S. Environmental Protection Agency. 2008, revised 2010. Reregistration Eligibility Decision Document for Tetramethrin.

- Thoreby, E. (author), Williams, M.M. (editor), Lah, K. (updater) 2011. Tetramethrin. Toxipedia.

- University of Hertfordshire Pesticide Properties Database 2021. Tetramethrin.

- ECHA, (updated 21 10 2018) Tetramethrin

2019, 2020: Permex22E used on Hvar in the insect suppression fogging programme.

THIAMETHOXAM. Neonicotinoid.

Possible adverse effects: Highly toxic to aquatic life, with acute and lasting effects; highly toxic to bees; toxic to earthworms; in humans, can be harmful through skin contact, inhalation, and especially ingestion; can cause nausea, vomiting, diarrhoea, abdominal pain, dizziness, headache; ingestion can cause seizures, coma, hypothermia, respiratory failure, hypotension, ventricular dysrhythmias and death.

EU: not approvedECHA: approved PT18 01/02/2015 - 31/01/2025.

Products: Actara 25WG, Actara 240SC, Cruiser SB, Centric, Flagship, Meridian, Optigard, Platinum (not on the ECHA approved list as at 6th May 2019). ECHA approved products: Agita 10WG, AGITA 100 PLUS, AGITAGARD 10WG, AGITA®10wg, Ditex, MS Thia-Fly (Market area Austria, Belgium, Bulgaria, Croatia, Cyprus & 22 more); AGITA 1GB (Market area France Spain, Switzerland, United Kingdom).

Croatia FIS/MIZ: Actara 25WG, Actara 240SC not approved

Sources: - ECHA 2019. Thiamethoxam Substance information.

- PubChem Open Chemistry Database. 2021. Thiamethoxam

- Coulon, M., Schurr, F., Martel, A.-C., Cougoule, N., Bégaud, A., Mangoni, P., Dlamon, A., Alaux, C., Le Conte, Y., Thiéry R., Ribière-Chabert, M., Dubois, E. 2018. Metabolisation of thiamethoxam (a neonicotinoid pesticide) and interaction with the Chronic bee paralysis virus in honeybees. Pesticide Biochemistry and Physiology, 144: 10-18

- University of Hertfordshire Pesticide Properties Database 2021. Thiamethoxam.

- Tosi, S., Nieh, J.C. 2017. A common nicotinoid pesticide, thiamethoxam, alters honey bee activity, motor functions and movement to light. Nature Scientific Reports 7: article number 15132.

- Toxnet (Toxicology Data Network) 2011, updated 2012. Thiamethoxam.

USED ON HVAR Actara used by individuals cultivating olives, vines, etc. (see 'Starigrad Plain: Our Survey')

TRICHLORFON. Organophosphate.

Possible adverse effects: Highly toxic to birds, bees, and aquatic organisms, toxic to fish; in humans, possible carcinogen; suspected to cause reproductive problems and birth defects; can cause vomiting, diarrhoea and abdominal cramps; affects the nervous system: can cause confusion, headaches, irritability, speech difficulties, memory and concentration loss; when inhaled, causes breathing problems, pulmonary oedema, sometimes nose-bleeds; eye contact can cause redness and bleeding, tears, blurred vision; skin contact can cause sweating and muscle contractions; severe poisoning affects the central nervous system and can cause loss of coordination (ataxia), slurred speech, weakness, fatigue, paralysis, unconsciousness, and even death; symptoms such as cramps, tingling, numbness in the legs followed by incoordination and paralysis sometimes come on 1-4 weeks after exposure and can leave permanent disability.

EU /ECHA / Croatia FIS/MIZ: Not approved.

Sources: - Toxnet (Toxicology Data Network) 1983, updated 2018. Trichlorfon

- Extension Toxicology Network (Extoxnet) 1993. Trichlorfon. (Pesticide Information Project, Cornell University)

- National Center for Biotechnology Information. PubChem Compound Database. 2005, modified 2018. Metrifonate -TRICHLORFON.

- University of Hertfordshire Pesticide Properties Database 2021. Trichlorfon.

USED ON HVAR: for many years trichlorfon was distributed to households together with rat poison (Ratimor, see below), previously in flimsy cellophane packaging. In tablet form, it was intended for use down toilet pans: when used, it most probably finished in the sea from seaside properties, or in the soil from soak-away septic tanks.

*Dangerous poisons in flimsy packaging. Photo: Vivian Grisogono*.

TRICOSENE. Chemical compound: muscalure, Z-9-tricosene, cis-tricos-9-ene, muscamone

Possible adverse effects: Irritant to skin and eyes on contact; inhalation can cause irritation to the respiratory tract; highly toxic to aquatic invertebrates

EU: Not approved ECHA: Approved PT19, repellants and attractants, 01/10/2014 - 30/09/2024.

Products: Quick Bayt (imidacloprid with tricosene), Maxforce Fly Spot Bait, Bonanza Fly Bait, Stimukil Fly Bait.

Croatia FIS: Quick Bayt not approved MIZ: Quick Bayt approved August 2009

Sources: - ECHA 2019. Tricosene Factsheet.

- University of Hertfordshire Bio-Pesticides DataBase. 2021. Muscalure, Z-9-tricosene.

- PubChem Open Chemistry Database, 2021. Tricosene

USED ON HVAR DDD programme, on rubbish tips: 2018: Quick Bayt®, Hvar Town region, 3rd July, 2 kg; Stari Grad region, 3rd July, 25th July, 15th July, 6th September 2018, 2 kg.

2020: Quick Bayt used around the Jelsa Council region (DDD programme)

2. SYNERGIST (INERT SUBSTANCE / MIXER)

PIPERONYL BUTOXIDE (PBO). Pyrethroid synergist.

Possible adverse effects: very toxic to aquatic life, with long-lasting effects; may cause birth defects, including holoprosencephaly (HPE); may delay mental development in infants; animal studies show possible damage, including tumours, in mice and rats.

EU: not assessed, not classified as a plant protection product. ECHA: 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether (Piperonyl butoxide/PBO) approved.

Products: Permex 22E, Cymina Ultra (Cypermethrin, Tetramethrin), Cymina Plus (Cypermethrin, Tetramethrin) Neopitroid Premium (Permethrin & D-Allethrin)

Croatia FIS: Permex 22E, Cymina Ultra, Cymina Plus, Neopitroid Premium not authorized. MIZ: Permex 22E approved April 2012. Cymina Ultra approved February 2011. Neopitroid Premium approved July 2011. Cymina Plus not approved

Sources: - Okamiya, H., Mitsumori, K., Onodera, H., Ito, S., Imazawa, T., Yasuhara, K., Takahashi, M. 1998. Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats. Archives of Toxicology 72 (11): 744-750.

- Khan, M.Z. & Law, F.C.P. 2005. Adverse effects of pesticides and related chemicals on enzyme and hormone systems of fish, amphibians and reptiles: a review. Proceedings of the Pakistan Academy of Science 42 (4): 315-323.

- U.S. Environmental Protection Agency. 2006. Reregistration Eligibility Decision for Piperonyl Butoxide (PBO)

- Muguruma, M., Nishimura, J., Jin, M., Kashida, Y., Moto, M., Takahashi, M., Yokouchi, Y., Mitsumori, K. 2006. Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice. Toxicology 228 (2-3): 178-187.

- Horton, M. K., Rundle, A., Camann, D.E., Boyd Barr, D., Rauh, V.A., Whyatt, R. M. 2011. Impact of Prenatal Exposure to Piperonyl Butoxide and Permethrin on 36-month Neurodevelopment. Pediatrics.

- ECHA (updated 15/08/2018) Piperonyl Butoxide

- Everson, J.L., Sun, M.R., Fink, D.M., Heyne, G.W., Melberg, C.G., Nelson, K.F., Doroodchi, P., Colopy, L.J., Ulschmid, C.M., Martin, A.A., McLaughlin, M.T., Lipinski, R.J. 2019. Developemntal Toxicity Assessment of Piperynol Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study. Environmental Health Perspectives, 127, 10

For an overview of inert substances, please refer to the United States Environmental Protection Agency listing: Pesticide Registration, Inert Ingredients.

USED ON HVAR in Permex 22E for adult insect suppression 'fogging' spraying and dispersion (see Permethrin or Tetramethrin, above)

3. FUNGICIDES (Agricultural fungicides are not included in the ECHA list of approved chemical substances)

AZOXYSTROBIN (substance group strobilurin)

Possible adverse effects: highly toxic to aquatic organisms and the aquatic environment, with long-lasting effects; highly toxic to hoverfly larvae; toxic to fish, earthworms; in humans, suspected possible carcinogen; can be fatal if swallowed; highly toxic if inhaled; harmful if absorbed through the skin; skin and eye irritant.

EU: Approved 01/01/2012 - 31/12/2024

Products: Universalis (with Folpet), Amistar 250SC

Croatia FIS: Universalis approved 21/05/2007-31/12/2023; Amistar 250SC approved 19/06/2009-31/12/2025

Sources: - PubChem 2021. Azoxystrobin.

- University of Hertfordshire Pesticide Properties Database 2021. Azoxystrobin.

- United States Environmental Protection Agency 2016. Azoxystrobin, Conditional Registration.

- United States Environmental Protection Agency 1997. Azoxystrobin. Pesticide Fact Sheet, for Conditional Registration.

USED ON HVAR: Universalis is used, especially on vines (see 'Starigrad Plain: Our Survey')

ON HVAR 2021: A chemical analysis by the Kudzu Science laboratory from a hair sample submitted in February revealed the presence of azoxystrobin in a 72-year-old resident of Pitve

BIXAFEN substance group pyrazolium

Possible adverse effects: highly toxic to fish; very toxic to aquatic life, with long-lasting effects; toxic to birds, earthworms, aquatic invertebrates and algae; slightly toxic to honeybees; in humans, probable reproduction/developmental toxin

EU: approved 01/10/2013-31/05/2025

Product: Ascra Xpro EC (fluopyrum, protocionazole, bixafen)

Croatia FIS: Ascra Xpro approved 01/12/2017-31/07/2022

Sources:

PPDB, 2021. Bixafen

PubChem 2021. Bixafen

BOSCALID substance group carboxamide

Possible adverse effects: toxic to the aquatic environment, with long-lasting effects; moderately toxic to fish, birds and earthworms; may affect foraging capacity in honeybees; in humans: possible carcinogen; possible effects on reproduction and development

EU: Approved 01/08/2008 - 31/07/2022

Products: Cantus; Signum (boscalid and pyraclostrobin); Bellis (boscalid and pyraclostrobin)

Croatia FIS: Cantus approved approved 09/12/2004-31/12/2023. Signum approved 29/12/2006-31/12/2023; Bellis approved 04/01/2008-31/12/2023

Sources: - PubChem 2021. Boscalid

- University of Hertfordshire Pesticide Properties Database 2021. Boscalid

- Liao, L-H., Wu, W-Y., Dad,A., Berenbaum, M.R. 2019. Fungicide suppression of flight performance in the honeybee (apis mellifera) and its amelioration by quercetin. Proceedings of the Royal Society, Biological Sciences

2019: the Agriculture Ministry's Department of Scientific Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Signum (19/06/2019)

ON HVAR 2021 Boscalid identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

CALCIUM CHLORIDE substance group: inorganic compound

Possible adverse effects: toxic if swallowed; can cause serious respiratory problems; can cause severe eye irritation.

EU: not approved

Product Cuprablau Z Ultra Croatia FIS: Cuprablau Z Ultra not approved

Souces: - Pub Chem 2005 / 2021. Calcium chloride

- University of Hertfordshire 2021. Pesticide Properties DataBase Calcium chloride

CALCIUM DIHYDROXIDE

Possible adverse effects: corrosive; toxic for aquatic life; in humans: skin irritant; causes serious eye irritation, possible respiratory tract irritant;

[EU: Calcium hydroxide approved from 01/07/2015, not approved as at 2021] ECHA: Bordeaux Mixture approved. [approved PT03 (veterinary hygiene) 01/05/2018 - 30/04/2028.]

Product: Bordeaux Mixture.

Croatia FIS: Bordoška juha caffaro 20WP approved 08/07/2004.-31/12/2023; Bordoška juha 20WP manica approved 24/11/2006.-31/12/2023.

Sources: ECHA Infocard 2021. Bordeaux mixture; reaction products of copper sulphate with calcium dihydroxide.

- PubChem 2006/2021. Calcium Dihydroxide (Calcium hydroxide, hydrate (compound)

- ECHA Infocard 2020. Calcium Dihydroxide

- Lafarge / Tarmac. 2014. Calcium Dihydroxide: Product Safety Sheet

CAPTAN substance group phthalimide

EU 01/10/2007 - 31/07/2022

Possible adverse effects: highly toxic to aquatic life, hazardous to aquatic environment; mod birds, earthworms, aquartic invertebrates, algae; in humans, acutely toxic if inhaled; suspected carcinogen; suspected endocrine disruptor; skin and eye irritant; may cause contact dermatitis; possibly a skin sensitiser,

Products: Captan WP 50, Captan 80 WG, Captan ST-S, Merpan 80 WDG, Kastor (Stoper), Zato Plus

Croatia FIS: Captan WP 50 approved 01/03/2006-31/12/2023; Captan 80 approved 21/01/2008-31/12/2023; Captan ST-S approved 03/2/1997-31/12/2023. Merpan 80 WDG approved 29/04/2003-31/12/2023. Kastor approved 05/12/2003-31/12/2023.

Sources:

PubChem 2021. Captan

PPDB 2021. Captan

CARBENDAZIM substance group benzimidamole

Possible adverse effects: highly toxic to aquatic organisms and the aquatic environment, with long-lasting effects; toxic to earthworms; moderately toxic to honeybees; in humans, may cause genetic defects; may damage fertility and the unborn child;

EU: Not approved

Product: Tilt CB 187.5 FW (carbendazim and propiconazole)

Croatia FIS: Tilt CB 187.5FW not approved

Sources: - PubChem 2021. Carbendazim

- University of Hertfordshire Pesticide Properties Database 2021. Carbendazim

CHLOROTHALONIL substance group chloronitrile

Possible adverse effects: highly toxic to fish; very toxic to aquatic life with long-lasting effects; toxic to birds, honeybees, earthworms; in humans: can be fatal if swallowed or inhaled; possible carcinogen; can affect reproduction and development; possible endocrine disruptor; causes serious eye damage; can cause respiratory tract irritation; can cause allergic skin reaction

EU: not approved,

Product: Folio Gold

Croatia FIS: Folio Gold authorization withdrawn 20/11/2019

Sources: - PubChem 2021. Chlorothalonil

- PPDB Pesticide Properties Database University of Hertfordshire. 2021. Chlorothalonil

COPPER COMPOUNDS

Possible adverse effects: highly toxic to fish, birds, aquatic invertebrates, organisms and plants; toxic to bees and earthworms; sheep, chickens; persists in the soil. In humans can cause nausea, irritation of respiratory tract and skin, eczema. Eye contact can cause conjunctivitis, inflammation of the eyelid lining, excess fluid build-up in the eyelid, clouding of the cornea, cornea tissue deterioration due to ulceration in the eye's mucous membrane.

Long-term, excessive exposure leads to the risk of heavy metal poisoning, including liver disease, brain damage, kidney and intestinal problems, anaemia, mutagenic potential; possible damaging effects on reproduction and development. Symptoms include: a metallic taste in the mouth, burning pain in the chest and abdomen, intense nausea, vomiting, diarrhoea, headache, sweating, shock, disrupted urination leading to yellowing of the skin. People with Wilson's disease (in which copper is absorbed and stored excessively in the body01/10/2013-31/05/2025), are at special risk of poisoning from copper-based pesticides.

EU: Copper compounds, Bordeaux Mixture, copper oxide, copper oxychloride, copper hydroxide approved 01/01/2019-31/12/2025

Products: Bordeaux Mixture (combination of copper sulphate and hydrated lime / calcium dihydroxide, see above); Bordoška juha Caffaro 20WP (copper compounds, Bordeaux Mixture), Bordoška juha 20WP Manica (copper compounds, Bordeaux Mixture); Kocide 3000 (copper hydroxide); Champ®Formula 2 (copper hydroxide), Champion WG50; Champion Flow SC; Comac (copper hydroxide), Wetcol 3 Copper Fungicide (tetracopper tricalcium sulphate and soluble calcium), Bordocop, Nordox 75WG (copper(I) oxide), Cuprablau Z (copper compounds, copper oxychloride); Cuprablau Z 35WG (copper compounds, copper oxychloride); Cuprocaffaro 50WP; Neoram WG (copper oxychloride) Copper Key Flow (copper oxychloride), Codimur SC (copper oxychloride)

Croatia FIS: Bordoška juha caffaro 20WP approved 08/07/2004.-31/12/2023; Bordoška juha 20WP manica approved 24/11/2006-31/12/2023. Champion Flow SC approved 17/06/1997-31/12/2023. Champion WG50 approved 21/01/2008.-31/12/2023. Cuprablau Z 35WG approved 17/04/2019-01/01/2022; Cuprocaffaro 50WP approved 17/04/2019-01/01/2022; Neoram WG approved 24/01/2008-31/12/2023; Nordox 75WG approved 24/01/2002-31/12/2023. Not approved: Modra galica; Cuprablau Z Ultra; Modra Galica (Scarmagnan) registration withdrawn on 01/07/2016; Champion and Cuprablau-Z registration withdrawn on 01/01/2020, final deadline for sales of stocks 01/07/2020, final use-by date 01/07/2021.

Spraying vines. Photo: Vivian Grisogono — *Spraying vines, 30th April 2019. Photo: Vivian Grisogono*

COPPER SULPHATE

Possible adverse effects: toxic to fish, aquatic invertebrates, aquatic plants, algae, birds, earthworms. In humans: harmful if inhaled, can cause serious eye problems. Associated with increased risk of potentially malignant oral submucous fibrosis, which can lead to oral squamous cell carcinoma.

EU: Tribasic copper sulfate approved, 01/01/2019 - 31/12/2025.

Product: Bordeaux Mixture. (combination of copper sulphate and hydrated lime / calcium dihydroxide)

Croatia FIS: Bordoška juha caffaro 20WP approved 08/07/2004-31/12/2023; Bordoška juha 20WP manica approved 24/11/2006-31/12/2023.

Sources: - University of Hertfordshire: Pesticide Properties Database. 2021. Copper Sulphate.

- University of Hertfordshire: Pesticide Properties Database. 2021. Bordeaux Mixture.

- Rodrigues, C.G., Krüger, A. P., Barbosa, W. F., Guedes, R. N. C. 2016. Leaf Fertilizers Affect Survival and Behavior of the Neotropical Stingless Bee Friesella schrottkyi (Meliponini: Apidae: Hymenoptera). Journal of Economic Entomology, Vol.109, 3, pp 1001-1008.

- Mathew, P., Ravi, D.A., Varghese, S.S., Manojkumar, A.D. 2015. Effect of copper-based fungicide (bordeaux mi x ture) spray on the total copper content of areca nut: Implications in increasing prevalence of oral submucous fibrosis. Journal of International Society of Preventive and Community Dentistry.

- European Food Safety Authority. 2008. Conclusion on the peer review of copper compounds. Scientific Report 187, 1-101.

- EXTOXNET Extension Toxicology Network. 1994. Copper Sulphate.

USED ON HVAR: Copper-based compounds, such as Nordox, and especially Copper Sulphate and Bordeaux Mixture, are widely used on vines, especially on the north side of the island, also on other crops (see 'Starigrad Plain: Our Survey')

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use copper-based pesticides fungicides (22.02.2019, 14.03.2019, 15.03.2019 (for olives), 15.03.2019 (for vines), 12th April 2019 (for vegetables), 19.06.2019, 26.07.2019)

2019: Nordox or Cuprablau or Bordeaux Mix (Bordoška juha) recommended by a well-respected Hvar olive oil producer to be used in January, February, March and November against olive leaf spot (spilocaea oleagina Cast. Croatian: paunovo oko); Neoram combined with mineral oil recommended in January against scale insects (coccoidea, Croatian: štitašte uši); Neoram and Nordox recommended against olive leaf spot in September; Neoram as an alternative against olive leaf spot in November.

Sprayed vines. Photo: Vivian Grisogono — *Sprayed vines, June 12th 2018. Photo: Vivian Grisogono*

CYMOXANIL substance group cyanoacetamide oxime

Possible adverse effects: very toxic to aquatic life and the aquatic environment, with long-lasting effects; in humans: highly toxic if swallowed; reproductive toxicity, suspected of damaging fertility and the unborn child; skin irritant; eye irritant; prolonged exposure causes organ damage

EU: Approved 01/09/2009 - 31/08/2021.

Product: Antracol Combi WP 76 (Cymoxanil and Propineb) Croatia FIS: Antracol Combi WP 76 and other Antracol products not approved

Sources: PubChem 2021. Cymoxanil.

PPDB Pesticide Properties Database, University of Hertfordshire. 2021. Cymoxanil

EFSA 2008. Conclusion regarding the peer review of the pesticide risk assessment of the active substance cymoxamil. EFSA Scientific Report 167, 1-116.

CYPRODINIL -substance group anilinopyramidine

Possible adverse effects: highly toxic to the aquatic environment, with long-lasting effects. Highly toxic to aquatic invertebrates; toxic to fish; moderately toxic to birds and earthworms; in humans: possible reproduction and development effects; can cause allergic reactions in skin; irritant to respiratory tract, eyes, skin; skin sensitizer.

EU: approved 01/05/2007-30/04/2022.

Products: Chorus 75WG, Chorus 50WG, Switch 62,5WG (cyprodinil and fludioxonil)

Croatia FIS: Chorus 75WG approved 27/07/2012-27/07/2022, Chorus 50WG approved 06/09/2005-31/12/2023, Switch 62,5WG approved 07/02/2007-31/12/2023.

ON HVAR 2021 Cyprodinil identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

DIFENOCONAZOLE, substance group triazole

Possible adverse effects: very toxic to fish, aquatic plants and algae, with long-lasting effects; harmful to bees; can contaminate bee pollen; moderately toxic to birds and mammals; in humans, possible carcinogen; possible endocrine disruptor; harmful if swallowed or inhaled; can cause serious eye irritation

EU: Approved 01/01/2009 - 31/12/2021.

Product: Difcor

Croatia FIS: Difcor approved 14/06/2017-31/12/2023

Sources: -PubChem 2021. Difenoconazole (Compound)

- PPDB University of Hertfordshire: Pesticide Properties Database 2021. Difenoconazole

- Leite, D.T., Sampaio, R.B:, Santos, J.N., Chambo, E.D., Carvalho, C.A.L., Sodré, G.S. 2018. Toxicity of Fenpyroximate, Difenoconazole and Mineral oil on Apis Mellifera L. Sociobiology 65 (4) 737-743. 44 references

- McArt, S.H., Fersch, A.A., Milano, N.J., Truitt, L.L., Böröczky, K. 2017. High pesticide risk to honey bees despite low focal crop pollen collection during pollination of a mass blooming crop. Scientific Reports 7, 46554. 55 references

- USEPA 2012. Difenoconazole Technical Product Label

- Marek Kubik, Janusz Nowacki, Andrzej Pidek, Zofia Warakomska, Lech Michalczuk, et al.. 2000. Residues of captan (contact) and difenoconazole (systemic) fungicides in bee products from an apple orchard. Apidologie, Springer Verlag, 31 (4), pp.531-541. 11 references

ON HVAR: Difcor recommended by a well-respected Hvar olive oil producer for use in April 2019 against olive leaf spot (spilocaea oleagina Cast. Croatian: paunovo oko)

DIMETHOMORPH substance group morpholine

Possible adverse effects: toxic to fish, aquatic invertebrates, crustaceans and plants, with long-lasting effects; hazardous to the aquatic environment; possibly affects honeybees through accumulation in pollen; slight risk for bumblebees and birds; moderately toxic to earthworms; can affect soil bacteria, impacting on soil nitrification and ammonification; in humans: irritant to respiratory tract, skin and eyes; possibly causes chromosome aberrations; possibly affects reproduction and development

EU: Approved 01/10/2007-31/07/2022

Products: Acrobat MZ WG (dimethomorph with mancozeb), Cabrio Team (dimethomorph and pyraclostrobin)

Croatia FIS: Acrobat MZ WG approval withdrawn 04/07/2021; Cabrio Team not approved

Sources: - PubChem 2021. Dimethomorph

- PPDB Pesticide Properties Database University of Hertfordshire. 2021. Dimethomorph

- Böhma, F., Bischoff, G., Zebitz, C.P.W., Rosenkranz, P., Wallner, K. 2018. Pesticide residue survey of pollen loads collected by honeybees (Apis mellifera) in daily intervals at three agricultural sites in South Germany. PLoS One published online July 6th 2018.

- Wang, C., Zhang, Q., Wang, F., Liang, W., 2017. Toxicological effects of dimethomorph on soil enzymatic activity and soil earthworm (Eisenia fetida) Chemosphere 169 316-323

- Cycoń, M., Piotrowska-Seget, Z., Kozdrój, J. 2010. Responses of indigenous microorganisms to a fungicidal mixture of mancozeb and dimethomorph added to sandy soils. International Biodeterioration and Biogredation 64 (4) 316-323

DIMOXYSTROBIN, substance group strobilurin

EU: approved o1/01/2006 - 31/01/2022

Possible adverse effects: highly toxic to aquatic life with long-lasting effects, highly toxic to fish, earthworms, aquatic invertebrates; toxic to honeybees, birds, sediment dwelling organisms, algae; in humans: endocrine disruptor, suspected carcinogen, suspected of reproduction / development effects - suspected of damaging unborn child

Product: Pictor (dimoxystrobin and boscalid)

Croatia FIS: Pictor approved 29/12/2006-31/12/2023

Sources:

PubChem 2021. Dimoxystrobin

PPDB 2021. Dimoxystrobin

DITHIANON, substance group quinone

Possible adverse effects: very toxic to fish, aquatic life, hazardous to the aquatic environment; moderately toxic to birds, earthworms; in humans: toxic; possible carcinogen; possible liver and kidney toxicant; if swallowed, may cause nausea, vomiting and diarrhoea; can cause serious eye irritation

EU: Approved 01/06/2011 - 31/08/2024

Product: Pergado D (dithianon, mandipropamid)

Croatia FIS: Pergado D approved 28/01/2019-31/07/2024

Sources: - PubChem 2021. Dithianon

- PPDB Pesticide Properties Database University of Hertfordshire. 2021. Dithianon

FLUDIOXONIL substance group phenylpyrrole

EU: approved 01/11/2008 - 31/10/2022

Possible adverse effects: highly toxic to aquatic life, with long-lasting effects; highly toxic to aquatic invertebrates, fish; damaging to birds, earthworms, aquatic crustaceans, sediment dwelling organisms, aquatic plants, algae; in humans, suspected carinogen; suspected of damaging the unborn child; eye and skin irritant.

Products: Switch 62,5WG (cypronidil & fludioxonil), Maxim 025 FS, Geoxe

Croatia FIS - Switch 62,5WG approved 07/02/2007-31/12/2023, Maxim approved 12 4 1999-31.12.2023, Geoxe 2 5 2015-31.10.2021

Sources: PubChem 2021. Fludioxonil

PPDB 2021 Fludioxonil

FLUOPYRAM, substance group benzamide, pyramide

Possible adverse effects: very toxic to fish, aquatic plants and algae, with long-lasting effects; slightly toxic to bees, birds, earthworms; in humans, can cause serious eye irritation; possibly causes damage to nervous system; affects reproduction, possibly damages the unborn child.

EU: Approved 01/02/2014 - 31/01/2024

Products: Luna ® Privilege (fluopyram); Luna Care (fluopyram with fosetyl) Luna Experience (fluopyram with tebuconazole), Luna Sensation (fluopyram with trifloxystrobin), Velum Prime

Croatia FIS: Luna Privilege approved 09/02/2015 - 31/01/2025; Luna Care approved 23/04/2020 - 30/04/2022; Luna Experience approved 19/01/2015 - 31/08/2020; Luna Sensation approved 09/07/2019 - 31/01/2025.

Sources: - University of Hertfordshire: Pesticide Properties Database, 2021. Fluopyram

- Bayer Crop Science Safety Data Sheet, 2017. Luna Experience SC400

USED ON HVAR Luna Experience, Luna Sensation and Luna Privilege used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

ON HVAR 2021 Fluopyram identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

FLUXAPYROXAD substance group pyrazolium

Possible adverse effects: very toxic to aquatic life, with long-lasting effects; toxic to birds, earthworms, fish, aquatic invertebrates, aquatic custaceans, aquatic plants, algae; somewhat toxic to honeybees; in humans: suspected carcinogen, possible reproduction / development effects, possible eye irritant

EU: approved 01/01/2013 - 31/05/2025.

Product: Priaxor EC (fluxapyroxad, pyraklostrobin)

Croatia FIS: Priaxor EC approved 24/10/2017 - 31/01/2022.

Sources: PPDB 2021. Fluxopyroxad

PubChem 2021. Fluxapyroxad

FOLPET (synthetic phthalimide)

Possible adverse effects: highly toxic to fish and aquatic organisms; moderately toxic to earthworms; causes developmental effects in animals; in humans: probable human carcinogen; possibly disrupts fertility; toxic if inhaled; causes serious eye irritation; can cause allergic skin reactions. ECHA warnings: hazardous to the environment and human health

EU: Approved 01/10/2007 - 31/07/2022. ECHA: approved under PT 06 (preservatives for products during storage), 07 (film preservatives), 09 (fibre, leather, rubber and polymerised materials preservatives)

Products: Universalis (folpet and azoxystrobin), Folpet 80 WDG, Folpan 50 WP, Phoenix®, Mikal Flash (folpet and fosetyl-al), Mikal (folpet and fosetyl-al), Mikal Premium F (folpet, fosetyl, iprovalicarb), Pergado F (folpet and mandipropamid)

Croatia FIS: Universalis approved 21/05/2007-31/12/2023., Mikal Flash approved 30/11/2006-31/12/2023, Mikal Premium F approved 29/11/2007-31/12/2023, Pergado F approved 26/11/2007-31/12/2023. Mikal and Folpan 50WP not approved

Sources: - PubChem Open Chemistry Database. 2021. Folpet.

- University of Hertfordshire: Pesticide Properties Database. 2021. Folpet.

- United States Environmental Protection Agency 1999. R.E.D. facts. Folpet.

USED ON HVAR Mikal, Mikal Flash, Universalis and Pergado used by farmers cultivating grapes and olives, etc (see 'Starigrad Plain: Our Survey')

30th April 2019, following heavy rain on Hvar, the Agriculture Ministry's Scientific Support

substance group strobilurin

EU: approved o1/01/2006 - 31/01/2022

Department advised grape growers to use Pergado F to prevent downy mildew (Plasmopara viticola)

12th April 2019, the Agriculture Ministry's Scientific Support Department advised grape growers to use Folpet fungicides preventively against black spot (Phomopsis viticola)

FOSETYL, FOSETYL-ALUMINIUM (Fosetyl-al) Organophosphate

Possible adverse effects: toxic to mammals, bees, birds, fish, aquatic invertebrates, algae, earthworms; possible human carcinogen; irritant if inhaled, can cause lung damage; causes serious eye irritation or damage; skin irritant

EU: approved 01/05/2007 - 30/04/2022. Fosetyl-Al not approved.

Products: Luna Care (fosetyl and fluopyram), Mikal Flash (folpet and fosetyl-al), Mikal (folpet and fosetyl-al), Mikal Premium F (folpet, fosetyl, iprovalicarb), Aliette Flash, Fosetyl-Al 80WP, Previcur Energy (propamocarb with fosetyl-al).

Croatia FIS: Luna Care approved 23/04/2020 - 30/04/2022; Mikal Flash approved 30/11/2006-31/12/2023, Mikal Premium F approved 29/11/2007-31/12/2023, Previcur Energy approved 23/05/2007-31/12/2023; Aliette Flash approved 27/11/2006-31/12/2023; Aliette WG, Mikal not approved

Sources: - PubChem Open Chemistry Database. 2021. Fosetyl-Al

- University of Hertfordshire: Pesticide Properties Database 2021. Fosetyl-al

- Toxnet (Toxicology Data Network) 1993, updated 2006, field updates 2010. Fosetyl-Aluminium

- United States Environmental Protection Agency 1991. R.E.D. facts. Fosetyl-Al

USED ON HVAR Mikal and Mikal Flash used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

IPROVALICARB substance group carbamate

Possible adverse effects: marine pollutant; very toxic to aquatic organisms; toxic to fish and aquatic invertebrates; may cause long-term adverse effects in the aquatic environment; moderately toxic to earthworms; in humans: possible carcinogen; corrosive to skin; highly damaging to health if swallowed (Melody Duo WP66,8)

EU: Approved 01/04/2016-31/03/2031

Products: Mikal Premium F (folpet, fosetyl, iprovalicarb), Melody Duo 66,8, Melody Duo WP 66,75 (propineb and iprovalicarb)

Croatia FIS: Mikal Premium F approved 29/11/2007.-31/12/2023. Melody Duo 66,8, Melody Duo WP 66,75 not approved

Sources: - PubChem 2021. Iprovalicarb

- PPDB Pesticide Properties Database University of Hertfordshire. 2021. Iprovalicarb

- US Environmental Protection Agency 2002. Iprovalicarb (Melody) Pesticide Tolerance 8/02.

- European Commission 2002. Review Report for the active substance iprovalicarb (working document)

- Bayer Crop Science 2004/2005. Safety Data Sheet Melody Duo WP66,8 10XI KG FS Internation

KRESOXIM METHYL (substance group strobilurin)

Possible adverse effects: very toxic to aquatic life; Highly toxic to the aquatic environment with long-lasting effects; moderately toxic to mammals; moderately toxic to earthworms; slightly toxic to honey bees (apis mellifera); in humans: probable carcinogen; irritant to respiratory tract, skin and eyes

EU: approved 01/01/2012 - 31/12/2024.

Product: Stroby WG

Croatia FIS: Stroby WG approved 25/07/2011-31/12/2025

Sources: - PubChem Open Chemistry Database. 2021. Kresoxim Methyl

- University of Hertfordshire: Pesticide Properties Database 2021. Kresoxim Methyl

- Tesoriero, D., Maccagnani, B., Santi, F., Celli, G. 2003. Toxicity of three pesticides on larval instars of Osmia cornuta: preliminary results. Bulletin of Insectology 56 (1) 169-171. 21 references

ON HVAR 2019: Stroby (or Nativo) recommended by a well-respected Hvar olive oil producer for use in May, August and November against olive leaf spot (spilocaea oleagina Cast. Croatian: paunovo oko)

MANCOZEB (substance group carbamate)

Possible adverse effects: toxic to fish, birds, aquatic invertebrates; moderately toxic to bees, earthworms, algae; in humans: possible thyroid disruptor; possible effects on reproduction and development; respiratory tract irritant; eye irritant

EU / ECHA: not approved

Products: Cadillac 80WP, Acrobat MZ WG (mancozeb, dimethomorph), Fubol Gold (mancozeb, metalaxyl), Mancozeb Blue 72 WG, Mancozeb Flowable with Zinc, Matco 8-64 (mancozeb with metalaxyl), Ridomil Gold MZ pepite (mancozeb, metalaxyl), Ridomil Gold MZ 68WP (mancozeb with metalaxyl), Pergado MZ (Mandipropamid with Mancozeb)

Croatia FIS: Cadillac 80WP approval withdrawn 04/07/2021, previously approved 15/06/2015-31/01/2021; Acrobat MZ WG approval withdrawn 04/07/2021, previously approved 29/12/2006-31/12/2023; Mancozeb Blue 72 WG approval withdrawn 04/07/2021; Ridomil Gold MZ pepite approval withdrawn 04/07/2021, previously approved 24/01/2011-24/01/2021, Pergado MZ approval withdrawn 04/07/2021, previously approved 21/05/2007-31/12/2023. Ridomil Gold MZ 68WP, Fubol Gold not approved

Sources: - PubChem Open Chemistry Database. 2021. Mancozeb

- University of Hertfordshire: Pesticide Properties Database 2021. Mancozeb

- Axelstad, M., Boberg, J., Nellemann, C., Kiersgaard, M., Jacobsen, P.R., Christiansen, S., Hougaard, K.S., Hass, U. 2011. Exposure to the widely used fungicide mancozeb causes thyroid disruption in rat dams but no behavioral effects in the offspring. Toxicological Sciences 120 (2) 439-446

- U.S. Environmental Protection Agency 2005. Mancozeb Facts - Pesticide Reregistration

ON HVAR: Ridomil and Cadillac used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

24th May 2019, the Agriculture Ministry's Scientific Support Department advised vegetable growers to use Ridomil Gold MZ preventively on potatoes, garlic, onions, tomatoes and peppers.

12th April 2019, the Agriculture Ministry's Scientific Support Department advised grape growers to use Mancozeb fungicides preventively against black spot (Phomopsis viticola)

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use mancozeb (26.04.2019, 10.05.2019, 26.06.2019); Acrobat MZ (12.04.2019, 05.06.2019, 18.06.2019., 03.07.2019); Pergado MZ (19.06.2019); Ridomil Gold MZ pepite (12.04.2019, 05.06.2019, 18.06.2019, 19.06.2019, 03.07.2019)

MANDIPROPAMID (substance group mandelamide)

Possible adverse effects: highly toxic to fish and aquatic organisms; moderately toxic to birds and earthworms; can be harmful to the liver and kidneys; eye irritant.

EU: Approved 01/08/2013 - 31/07/2023. [ECHA warning: hazardous to the environment.]

Products: Pergado F (mandipropamid, folpet), Pergado D (mandipropamid, dithianon), Pergado MZ (mandipropamid, mancozeb)

Croatia FIS: Pergado F approved 26/11/2007-31/12/2023, Pergado D approved 28/01/2019-31/07/2024, Pergado MZ approval withdrawn 04/07/2021, previously approved 21/05/2007-31/12/2023.

Sources: - PubChem Open Chemistry Database. 2021. Mandipropamid

- University of Hertfordshire: Pesticide Properties Database, 2021. Mandipropamid

ON HVAR: Pergado used especially by grape-growers (see 'Starigrad Plain: Our Survey')

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Pergado MZ (19.06.2019)

METALAXYL, METALAXYL-M (substance group phenylamide)

Possible adverse effects: toxic to bees, birds, fish, earthworms; in humans: can cause serious eye damage; skin irritant; very harmful if swallowed

EU: Metalaxyl approved 01/07/2010 - 30/06/2023; Metalaxyl-M approved 01/06/2020-31/05/2035.

Products: Folio Gold (metalaxyl, chlorothalonil), Fubol Gold (mancozeb, metalaxyl), Ridomil Gold MZ pepite (mancozeb, metalaxyl), Ridomil Gold MZ 68WP (mancozeb with metalaxyl), Ridomil Gold Plus 42,5 WP (metalaxyl-M, copper compounds, copper oxychloride); Ridomil Gold R (metalaxyl-M, copper compounds, copper oxychloride)

Croatia FIS: Ridomil Gold MZ pepite approval withdrawn 04/07/2021, previously approved 24/01/2011-24/01/2021; Ridomil Gold R approved 11/04/2017-30/06/2021; Folio Gold authorization withdrawn 20/11/2019; Ridomil Gold Plus 42,5 WP authorization withdrawn 01/01/2020; Ridomil Gold MZ 68WP, Fubol Gold not approved

Sources: - PubChem Open Chemistry Database. 2021. Metalaxyl-M

- University of Hertfordshire: Pesticide Properties Database 2021. Metalaxyl-M

ON HVAR: Ridomil used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

METIRAM (substance group carbamate)

Possible adverse effects: Moderately toxic to fish; highly toxic to aquatic invertebrates; highly toxic to aquatic life, with long-lasting effects; hazardous to the aquatic environment; moderately toxic to honeybees and earthworms; in humans: can cause skin and eye irritation; can cause anaemia; toxic if ingested or inhaled; can cause abdominal cramps, vomiting and diarrhoea if ingested; classified as a possible human carcinogen

EU: Approved 01/07/2006 - 31/01/2022

Products: Cabrio® Top (metiram & pyraclostrobin), Polyram DF

Croatia FIS: Cabrio Top approved 07/04/2011-07/04/2023; Polyram DF approved 02/02/2012-02/02/2022

Sources: - PubChem Open Chemistry Database. 2021. Met iram

- University of Hertfordshire: Pesticide Properties Database 2021. Met iram

- Toxnet (Toxicology Data Network) 1991, revised 2010. Metiram

ON HVAR: Cabrio® Top used by individuals cultivating vines, olives (see 'Starigrad Plain: Our Survey')

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised grape-growers in the Split-Dalmatia County to use the Metiram fungicide Polyram DF preventively against black spot (Phomopsis viticola) (12th April 2019)

PENCONAZOLE, (substance group triazole)

Possible adverse effects: toxic to bees, birds, fish, aquatic invertebrates and algae; in humans: suspected of damaging fertility or the unborn child; possible endocrine disruptor; very harmful if swallowed

EU: Approved 01/01/2012 - 31/12/2021.

Products: Topas 100EC, Penconazole 200 EW, Hockley Pencon 10

Croatia FIS: Topas 100EC approved 01/02/2007-31/12/2023

Sources: - ECHA Information on chemicals, inventory database (2019)

- PubChem Open Chemistry Database. 2021. Penconazole

- University of Hertfordshire: Pesticide Properties Database 2021. Penconazole

ON HVAR: Topas used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

PROPAMOCARB (substance group carbamate)

Possible adverse effects: Potentially harmful to herbivorous and insectivorous birds; moderately toxic to fish and honeybees; in humans: harmful if swallowed; skin irritant; possible endocrine disruptor; possible neurotoxicant

EU: Approved 01/10/2007-31/07/2022

Products: Previcur Energy (propamocarb with fosetyl-al); Previcur 670SL (propamocarb hydrochloride). Croatia FIS: Previcur Energy approved 23/05/2007-31/12/2023; Previcur 607SL not approved

Sources:- PubChem Open Chemistry Database. 2021. Propamocarb

- University of Hertfordshire: Pesticide Properties Database. 2021. Propamocarb

- EFSA Scientific report 2006. Conclusion on the peer review of propamocarb. EFSA 78, 1-80.

PROPICONAZOLE (substance group triazole)

Possible adverse effects: highly toxic to fish; toxic to aquatic organisms; in humans, highly irritant to eyes and skin; harmful if swallowed, inhaled or absorbed through the skin; can cause skin allergies; possible liver toxicant; possible endocrine disruptor; classified as possible carcinogen by USEPA.

EU: Not approved

Products: Tilt 250EC, Tilt CB 187.5 FW (carbendazim and propiconazole) Menara, Mantis, Banner Maxx.

Croatia FIS: Tilt 250EC, Tilt CB 187.5FW not approved

Sources: - University of Hertfordshire: Pesticide Properties Database 2021. Propiconazole

- U.S. Environmental Protection Agency, 2014. Tilt fungicide. Revised master label

- Chen, P-J., Moore, T., Nesnow, S. 2008. Cytotoxic effects of propiconazole and its metabolites in mouse and human hepatoma cells and primary mouse hepatocytes. Toxicology in vitro 22: 1476-1483

ON HVAR: Tilt used by individuals cultivating vines, olives (see 'Starigrad Plain: Our Survey')

PROPINEB (substance type: carbamate)

Possible adverse effects: highly toxic to aquatic life; toxic to bees, birds, earthworms; in humans: can cause organ damage, allergic skin reactions; toxic on skin contact; suspected as possible carcinogen, respiratory tract irritant.

EU: not approved

Products: Antracol®WPG70, Antracol®WP/70 (with zinc), Antracol Combi WP/76 (propineb, cymoxanil), Propineb 70%

Croatia FIS: Antracol®WPG70, Antracol®WP/70, Antracol Combi not approved

Sources: - PubChem Open Chemistry Database, 2021. Propineb

- University of Hertfordshire: Pesticide Properties Database 2021. Propineb

ON HVAR: Antracol used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

PROTHIOCONAZOLE (substance group triazolinthione)

Possible adverse effects: toxic to fish, aquatic invertebrates, aquatic crustaceans and sediment dwelling organisms; very toxic to aquatic life, with long-lasting effects; hazardous to the aquatic environment; toxic to honeybees and earthworms; in humans: can affect reproduction and development; possible endocrine disruptor; can cause skin irritation; possible irritant if inhaled.

EU: Approved 01/08/2008-31/07/2022

Products: Falcon Forte (prothioconazole, spiroxamine, tebuconazole); Ascra Xpro (fluopyram, prothioconazole, bixafen)

Croatia FIS: Falcon Forte approved 20/03/2019-31/07/2022; Ascra Xpro approved 01/12/2017-31/07/2022.

Sources: - PubChem 2021. Prothioconazole

- PPDB Pesticide Properties Database University of Hertfordshire. 2021. Prothioconazole

- Zhang, Z. Du, G., Gao, B., Hu, K., Kaziem A.E., Li, L., He, Z., Shi, H., Wang, M. 2019. Stereoselective endocrine-disrupting effects of the chiral triazole fungicide prothioconazole and its chiral metabolite. Environmental Pollution, 251 30-36

- CLH Report, Proposal for Harmonised Classification and Labelling. 2018. Substance name: Prothioconazole.

- EPA 2016. Prothioconazole; Pesticide Tolerances. Federal Register, The Daily Journal of the United States Government.

- EFSA 2007. Conclusion regarding the peer review of the pesticide risk assessment of the active substance prothioconazole. EFSA Scientific Report 106 1-98

PYRACLOSTROBIN (carbamate ester, substance group strobilurin)

Possible adverse effects: Highly toxic to fish, aquatic life, with long-lasting effects; hazardous to the aquatic environment with long-term effects; in humans: toxic, acutely dangerous if inhaled, can be fatal if swallowed; may cause respiratory irritation; causes eye and skin irritation; causes neurodegeneration; can cause nausea, headache, dizziness, chest pain

EU: Approved 01/06/2004 - 31/01/2022

Products: Cabrio® Top (pyraclostrobin & metiram), Baitai ® (pyraclostrobin & metiram), Cabrio Team ® (pyraclostrobin & dimethomorph), Signum (pyraclostrobin & boscalid), Bellis (pyraclostrobin and boscalid), Priaxor EC

Croatia FIS: Cabrio Top approved 07/04/2011-31/01/2023; Signum approved 29/12/2006-31/12/2023; Bellis approved 04/01/2008-31/12/2023; Priaxor EC approved 24/10/2017-31/01/2022.. Cabrio Team not approved

Sources: - PubChem Open Chemistry Database, 2021. Pyraclostrobin

- University of Hertfordshire: Pesticide Properties Database 2021. Pyraclostrobin

- Luz, A.L., Kassotis, C.D., Stapleton, H.M., Meyer, J.N. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPAR γ activation, in 3T3-L1 cells. Toxicology 393: 150-159

- Pearson, B.L., Simon, J.M., McCoy, E.S., Salazar, G., Fragola, G., Zylka, M.J. 2016. Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nature Communications 7, 11173

- United States Centers for Disease Control and Prevention. 2008. Acute Pesticide Poisoning Associated with Pyraclostrobin Fungicide - Iowa 2007 Morbidity and Mortality Weekly Rreport 56 (51) 1343-1345

ON HVAR: Cabrio® Top used by individuals cultivating vines, olives (see 'Starigrad Plain: Our Survey')

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Signum (19.06.2019)

ON HVAR 2021 Pyraclostrobin identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

PYRIMETHANIL (substance group anilinopyrimidine).

Possible adverse effects: toxic to aquatic life, with long-lasting effects; endocrine disruptor in tree frogs, causes liver and kidney damage in non-target species; toxic to earthworms; in humans, possible carcinogen; toxic through skin contact and inhalation

EU: approved 01/05/2007 - 30/04/2022

Products: Pyrus® 400SC, Scala Croatia FIS: Pyrus 400SC approved 09/05/2007-31/12/2023; Scala approved 12/09/2016-30/04/2022

Sources: - PubChem Open Chemistry Database, 2021. Pyrimethanil

- University of Hertfordshire: Pesticide Properties Database, 2021. Pyrimethanil

- Bernabo, I., Guardia, A., Macirella, R., Tripepi, S., Brunelli, E. 2017. Chronic exposure to fungicide pyrimethanil: multi-organ effects on the Italian tree frog (Hyla intermedia). Scientific Reports 7, 6869.

-Toxnet, Toxicology Data Network. 2004 / 2010. Pyrimethanil

USED ON HVAR: Pyrus® 400SC is used especially on vines. (see 'Starigrad Plain: Our Survey')

SPIROXAMINE (substance group morpholine).

Possible adverse effects: very toxic to aquatic life; in humans, suspected of causing damage to the unborn child; may cause damage to organs through prolonged or repeated exposure; harmful if swallowed or inhaled; can cause skin irritation and allergic reactions.

EU: Approved 01/01/2012 - 31/12/2023.

Products: Impulse®, Prosper®500 EC, Falcon (spiroxamine with tebuconazole), Falcon EC 460 (spiroxamine, tebuconazole, tridimenol), Falcon Forte (spiroxamine, prothioconazole, tebuconazole)

Croatia FIS: Falcon EC 460 approval withdrawn 31/08/2020, previously approved 10/02/2006-31/08/2020; Falcon Forte approved 20/03/2019-31/07/2022

Sources: - PubChem Open Chemistry Database. 2021. Spiroxamine

- University of Hertfordshire: Pesticide Properties Database 2021. Spiroxamine

- European Chemicals Agency, Substance Information. 2018. Spiroxamine

ON HVAR: Falcon used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

ON HVAR 2021 Spiroxamine identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

SULPHUR (inorganic compound)

Possible adverse effects: if inhaled can cause coughing, sneezing and respiratory impairment; skin contact can cause redness, itching and burning in sensitive individuals; eye contact can cause painful irritation, redness and tears; ingestion can cause nausea, vomiting and diarrhoea; can interfere with photosynthesis in plants.

EU: Approved 01/01/2010 - 31/12/2021.

Products: Chromosul 80 (Warnings: Chromosul 80 to be used no more than four times a year, and never when the vine is fully developed; should not be mixed with propamocarb, captan, heptenophos, oils, bupirimate and folpet.); Sugran (Chromosul WG), Sumpor prašivo; Sumpor WG 80, Sumpor SC 80; Sumpor Micro 80WP, Sumpor močivi tiosam 80 mikro, Sumporno prašivo

Croatia FIS: Chromosul 80 approved 04/09/1997-31/12/2023; Sugran (Chromosul WG) approved 03/02/2016 - 31/12/2022; Sumpor prašivo approved 21/09/2016-31/12/2022; Sumpor WG 80 approved 14/10/2016-11/12/2022; Sumpor SC 80 approved 25/05/1998-31/12/2023; Sumporno prašivo approved 13/09/2016-31/12/2023; Sumpor micro 80WP, Sumpor močivi tiosam 80 mikro not approved

Sources: - University of Hertfordshire: Pesticide Properties Database 2021. Sulphur

- Petit, A-N., Fontaine, F., Vatsa, P., Clément, C., Vaillant-Gaveau, N. 2012. Fungicide impacts on photosynthesis in crop plants. Photosynthesis Reseach 111 (3) 315-326

- Extension Toxicology Network (Extoxnet). 1995. Sulfur. (Pesticide Information Project, Cornell University)

ON HVAR: Chromosul used, especially by grape-growers (see 'Starigrad Plain: Our Survey')

TEBUCONAZOLE (substance group triazole)

Possible adverse effects: highly toxic to aquatic life, with long-lasting effects; toxic to bees, birds, earthworms; in humans: can damage the unborn child; possible human carcinogen; toxic if swallowed.

EU: Approved 01/09/2009 - 31/08/2022. ECHA: approved under PT07 (film preservatives), 08 (wood preservatives), 10 (construction material preservatives)

Products: Tebuconazole 3.6, Cogito (tebuconazole with propiconazole), Luna Experience (tebuconazole with fluopyram), Falcon 460EC (tebuconazole with spiroxamine), Falcon Forte (spiroxamine, prothioconazole, tebuconazole), Nativo 75WG (trifloxystrobin with tebuconazole).

Croatia FIS: Nativo approved 06/03/2008-31/12/2023; Luna Experience approved 19/01/2015-31/08/2022; Falcon EC 460 approval revoked 30/08/2020, previously approved 10/02/2006-31/08/2020; Falcon Forte approved 20/03/2019-31/07/2021.

Sources: - PubChem Open Chemistry Database. 2021. Tebuconazole

- University of Hertfordshire: Pesticide Properties Database 2021. Tebuconazole

ON HVAR: Luna and Falcon used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Falcon 460EC (18/06/2019, 26/07/2019); Luna Experience (14/03/2019, 10/05/2019, 24/05/2019, 18/06/2019, 26/06/2019, 26/07/2019), Nativo 75WG (08/03/2019, 14/03/2019, 15/03/2019, 12/04/2019, 02/05/2019, 24/05/2019, 27/05/2019, 05/06/2019, 18/06/2019, 19/06/2019, 03/07/2019)

2019: Nativo (alternatively Stroby) recommended by a well-respected Hvar olive oil producer against olive leaf spot (spilocaea oleagina Cast. Croatian: paunovo oko)

TRIADIMENOL (substance group triazole)

Possible adverse effects: highly toxic to aquatic life with long-lasting effects; hazardous to the aquatic environment; causes reproductive disruption in medaka fish and mammals;can harm Eremias argus lizards; causes neurobehavioural effects in rats; in humans: highly toxic if swallowed; may damage fertility; may harm the unborn child; may harm a child being breast-fed; causes eye irritation; causes mild skin irritation

EU: Not approved

Product: Falcon EC 460.

Croatia FIS: Falcon EC 460 approval revoked 30/08/2020, previously approved 10/02/2006-31/08/2020.

Sources: - PubChem 2021. Triadimenol

- PPDB Pesticide Properties Database University of Hertfordshire. 2021. Triadimenol

Wang, Z., Tian, Z., Zhang, W., Zhang, L., Diao, J., Zhou, Z. 2019. Stereoselective metabolism and potential adverse effects of chiral fungicide triadimenol on Eremias argus. Enironmental Science and Pollution Research 27, 7823-7834 (2020)

- Chu, S-H., Liao, P-H., Chen, P-J. 2016. Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish. Chemosphere 152 181-189

Walker, Q.D., Malman, R.D. 1996. Triadimefon and Triadimenol: Effects on Monoamine Uptake and Release. Toxicology and Applied Pharmacology 139 (2) 227-233

TRIFLOXYSTROBIN (substance group strobilurin)

Possible adverse effects: very toxic to fish, aquatic invertebrates and algae; very toxic to aquatic life with long-lasting effects; moderately toxic to sediment-dwelling organisms and aquatic plants; moderately toxic to earthworms; low toxicity to honeybees; in humans: can cause problems with reproduction and development; can cause eye irritation and allergic skin reactions.

EU: approved 01/08/2018-31/07/2033.

Products: Nativo 75WG (trifloxystrobin with tebuconazole). Luna Sensation (trifloxystrobin with fluopyram). Zato Plus (trifloxystrobin and captan). Fandango EC 200

Croatia FIS: Nativo approved 06/03/2008-31/12/2023; Luna Sensation approved 09/07/2019.-31/01/2025. Zato Plus approved 21/01/2008-31/12/2023. Fandango EC200 not approved

Sources: - PubChem Open Chemistry Database. 2021. Trifloxystrobin

- University of Hertfordshire: Pesticide Properties Database 2021. Trifloxystrobin

- Junges, C.M., Peltzer, P.M., Lajmanovich, R.C., Attademo, A.M., Cabagna Zenklusen, M.C., Basso, A. 2012. Toxicity of the fungicide trifloxystrobin on tadpoles and its effect on fish-tadpole interaction. Chemosphere 87 1348-1354.

ON HVAR Luna Sensation used by individuals cultivating vines, olives, etc (see 'Starigrad Plain: Our Survey')

2019: the Agriculture Ministry's Department of Expert Support for the Development of Agriculture and Fishing advised farmers in the Split-Dalmatia County to use Nativo 75WG (08/03/2019, 14/03/2019, 15/03/2019, 12/04/2019, 02/05/2019, 24/05/2019, 27/05/2019, 05/06/2019, 18/06/2019, 19/06/2019, 03/07/2019)

2019: Nativo (alternatively Stroby) recommended by a well-respected Hvar olive oil producer against olive leaf spot (spilocaea oleagina Cast. Croatian: paunovo oko)

ON HVAR 2021 Trifloxystrobin identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

ZINC SULPHIDE (inorganic compound)

Possible adverse effects: in humans, can be harmful if inhaled or swallowed; can cause skin or eye irritation; can cause headaches or nausea

[EU not listed]

Product: Cuprablau Z (copper hydroxide, calcium chloride complex, & zinc sulphide)

Croatia FIS: Cuprablau Z not approved

Sources:- ECHA 2021. Infocard: Zinc Sulphide

- PubChem Open Chemistry Database. 2021. Zinc Sulfide

- Fisher Science Education. 2015. Safety Data Sheet

- Angstrom Sciences Inc. 2015. Safety Data Sheet

4. LIMACIDE (MOLLUSCICIDE) ECHA APPROVAL CODE PT16, molluscicides, vermicides and products to control other invertebrates (against slugs, snails and other arthropods)

METALDEHYDE (Chemical compound)

Possible adverse effects: Highly toxic to aquatic organisms, with long-lasting effects; deadly to dogs and cats: Toxic to humans if swallowed or through skin contact or inhalation; can cause salivation, lethargy, abdominal pain, nausea, vomiting, and diarrhea, convulsions, hyperthermia, comas, and death

EU: approved, 01/06/2011-31/05/2023. ECHA: not approved

Products: Pužomor, Corry's slug, snail and insect killer, Bug-geta snail and slug pellets, Slugit, Slug-Tox, Certis Deal 5, Meridien, Carakol, Metalden, Metarex. Combined with insecticide Carbaryl in Lily Miller Slug, Snail and Insect Killer Bait, also for Ortho Bug-Geta Plus. ECHA: no approved related products

Croatia FIS: Pužomor approved 12/01/2005-31/12/2023. MIZ: Pužomor not approved

Sources: - PubChem Open Chemistry Database, 2021. Metaldehyde.

- University of Hertfordshire Pesticide Properties Database 2021. Metaldehyde.

- Toxnet (Toxicology Data Network), 1983, updated 2010. Metaldehyde.

- U.S. Environmental Protection Agency, 2007. Amendment to RED (Reregistration Eligibility Document) for Metaldehyde

USED ON HVAR: widely used as Pužomor in gardens and fields, with many documented fatalities among dogs and cats.

5. RODENTICIDES ECHA APPROVAL CODE PT14, rodenticides

BRODIFACOUM. Rodenticide - superwarfarin - 4-hydroxycoumarin vitamin K antagonist anticoagulant poison.

Possible adverse effects: highly toxic when ingested, causes haemorrhage, can be fatal to humans and animals alike; can be fatal through inhalation and skin contact; highly toxic to fish and birds; causes long-lasting damaging effects in aquatic environments

EU: Not approved ECHA: approved, PT14, 01/02/2012 - 30/06/2024.
Products: Ratimor, Ridak, Delicat, Sorexa Checkatube. ECHA as at 07.11.2019, 454 approved products including AGRIGARD PASTA BF-50, ALBAROD BF-50 PASTA, BRODI PASTE, BRODITEC P-50, BRODITEC P-50 CEREALI, ANTI-RAT Plus, Vahaplokid, ANTI-RAT Plus vaska briketes, ANTI-RAT Plus vaškiniai blokai, BRODI RAT BLOCK, BRODIFACOUM BB.

Croatia FIS/MIZ Ratimor products no longer approved

Sources: - ECHA 2019. Brodifacoum factsheet

- ECHA (updated 15/08/2018) Brodifacoum

- PubChem, Open Chemistry Database 2021 Brodifacoum

- University of Hertfordshire Pesticide Properties Database, 2021. Brodifacoum

- Toxnet (Toxicology Data Network) 1984, updated 2014. Brodifacoum

ON HVAR: Brodifacoum was on the list of pesticides recommended for use around Hvar Town, Stari Grad and the Jelsa Council area, under the Programme issued by the Split-Dalmatian County Public Health Institute for 2017, and in the Institute's Implementation Plan for 2018.

BROMADIOLONE. Rodenticide - anticoagulant - superwarfarin - 4-hydroxycoumarin vitamin K antagonist anticoagulant poison.

Possible adverse effects: Acutely toxic, can be fatal if swallowed, inhaled, or via skin contact; may damage fertility or the unborn child; can cause organ damage in humans; highly toxic to fish and aquatic life, also to earthworms.

EU: Not approved as from 31/05/2021 ECHA: approved, PT14, 01/07/2011 - 30/06/2024

Products: Ratimor wax blocks, Ratimor Bromadiolone Fresh Bait, Ratimor Bromadiolone Pasta Bait, Maki, Brodilon, Coumarin, Tomcat, Sarakat Bromabait, Contrac, Bromone, Maki, Super-Caid. ECHA: 496 related products approved.

Croatia FIS/MIZ Ratimor products no longer approved, Brodilon not approved

Sources: - ECHA 2019. Bromadiolone Factsheet

- PubChem, Open Chemistry Database, 2021. Bromadiolone

- University of Hertfordshire Pesticide Properties Database, 2021. Bromadiolone

- ECHA (updated 15/08/2018) Bromadiolone

USED ON HVAR, Ratimor (granules and wax blocks): 2016: Hvar Town and surrounds: May and October; Stari Grad and surrounds, April and October; Jelsa Council region, April-May and October 2016; 2017: Hvar Town region, May-June, 17th & 23rd November, total quantities 1010 kg granules 172 kg wax blocks; Stari Grad and surrounds, May and November, total: 787 kg; Jelsa Council region, May and November 2017. total 981 kg; 2018: Hvar Town region 22nd May, 3rd October, Ratimor granules 455 kg, wax blocks 22 kg; Stari Grad & surrounds, 22-24 May, 2-4 October; Jelsa Council region,18-21 May, 25th September - 4th October 2018. Ratimor has been delivered to households on Hvar twice a year for many years. It used to be delivered along with an insecticide, Trichlorfon (see above). Until 2017, the pesticides were distributed in flimsy cellophane packages, with the instructions on the inside. From 2018 - 2020, Ratimor was delivered to households in the Jelsa region in insecure cardboard boxes, without detailed instructions as to how to use the poisons, and without any guidance as to how to dispose of the box and poison after use.

2017, 2018 Brodilon used in the Sućuraj region

6. HERBICIDES. (Herbicides are authorized as 'plant protection products' and are not included in the ECHA list of biocidal chemical substances)

*Herbicide in Stari Grad field. Photo: Vivian Grisogono*

CHLOROTOLURON (substance group urea)

EU approved 01/03/2006-31/10/2022

Possible adverse effects: very toxic to aquatic life with long-lasting effects; moderately toxic to birds and honeybees; suspected carcinogen; suspected reproductive toxicity, causing harm to the unborn child

Products: Tolurex 50SC; Tornado Forte (Chlorotoluron & Diflufenican)

Croatia FIS: Tolurex 50SC approved 25/09/2015-31/10/2021, approval withdrawn 2021. Tornado Forte approved 03/06/2015-31/12/2022

Sources:

PPDB 2021. Chlorotoluron

PubChem 2021. Chlorotoluron

ON HVAR 2021 Chlorotoluron identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

DIFLUFENICAN (substance group carboxamide)

Possible adverse effects: highly toxic to aquatic life and the aquatic environment, with long-lasting effects; moderately toxic to birds and earthworms; in humans, possibly affects reproduction and development; eye irritant.

EU: approved 01/01/2008-31/12/2022.

Products: Tornado Forte (diflufenican and chlorotoluron), Alister New (Jodosulfuron + Mesosulfuron + Diflufenikan)

Croatia FIS: Tornado Forte approved 03/06/2015-31/12/2022. Alister New approved 26/09/2016-31/12/2022.

Sources:

PPDB 2021 Diflufenican

PubChem 2021 Diflufenican

GLYPHOSATE (substance group phosphonoglycine)

There are at least some 750 glyphosate-based herbicides available in the world markets. Eleven of them, including the widely used Roundup (Cidokor in Croatian), were banned in the EU in 2016.

Suspected possible adverse effects in humans: carcinogenic; neurotoxic; genotoxic; contributes to antibiotic resistance; influences pregnancy, fertility, and birth defects; endocrine disruptor; damages DNA, gut bacteria, organs including liver, kidneys and spleen; contributes to Parkinson's Disease and autism.

Possible environmental ill-effects: damage to water, fish, aquatic organisms, soil, soil organisms, bees, butterflies, gastropods, trees, plants

You can find a detailed presentation of the evidence of glyphosate's potential dangers in our article 'Glyphosate herbicides, Scientific Evidence'. For a description of the problems relating to glyphosate, see 'Glyphosate, GBH'.

EU: Glyphosate approved 16/12/2017 - 15/12/2022.

Products: Roundup / Cidokor, Cidokor Max, Cidokor Plus, Touchdown / Ouragan, Herkules, Herkules 480SL, Herkules Super, Glyfos, Oxalis, Boom Efekt, Roundup Bioactive, Roundup Rapid etc. etc.

Croatia FIS, Agrobase: Cidokor not approved;

FIS: Cidokor Max approved 09/06/2015-01/03/2022, Agroklub: not approved since 31/12/2018; Agrobase Croatia: registration withdrawn;

FIS: Cidokor Plus approved 24/11/2015-01/03/2022, Agroklub: not approved since 20/09/2018, Agrobase Croatia: registration withdrawn;

FIS, Agrobase: Ouragan System 4 approved 24/01/2012-24/01/2022;

FIS: Glyfos not approved; (Agrobase, Glyfos not listed)

FIS: Herkules approved 22/02/2017-01/03/2022; FIS: Herkules 480 SL not approved; FIS: Herkules Super not approved; (Agrobase; Herkules products not listed)

FIS: Oxalis not approved since 16/12/2018, Agrobase Croatia: Oxalis registered until 25/07/2021;

FIS: Roundup Bioactive approved 01/07/2016-01/03/2022; Agrobase Croatia: registration withdrawn;

FIS: Roundup Rapid approved 24/11/2015-01/03/2022; Agrobase Croatia: registration withdrawn.

FIS, Agrobase: Boom Effect approved 01/03/2012.-01/03/2022.

USED ON HVAR: Roundup (locally Cidokor) has been widely and intensively used on Hvar over many years, alongside other glyphosate-based herbicides such as 'Ouragan', 'Oxalis' and 'Boom Efekt'. (see 'Starigrad Plain: Our Survey')

2019, Cidokor, alternatively Herkules Super or Glyfos were recommended by a well-respected Hvar olive oil producer to be used on weeds in April and June.

ON HVAR 2021: A chemical analysis by the Kudzu Science laboratory from a hair sample submitted in February revealed the presence of glyphosate in a 72-year-old resident of Pitve

PENDIMETHALIN (substance group dimitroaniline).

EU: approved 01/09/2017-30/11/2024.

Possible adverse effects: very toxic to aquatic life, with long-lasting effects; highly toxic to freshwater fish, marine organisms; moderately toxic to earthworms; slightly toxic to birds; possible carcinogen (USEPA); reproduction/developmental effects, suspected endocrine disruptor; thyroid and liver toxicant; can cause headaches, dizziness, nausea, vomiting; skin sensitizer; skin and eye irritant; can irritate nose and throat; bioaccumulates.

Products: Stomp Aqua, Pendus 330EC

FIS: Stomp Aqua approved 20/10/2015-01/09/2023; Pendus 330EC approved 28/06/2016-01/09/2022.

Sources:

Pesticide Properties Database 2021. Pendimethalin

PubChem 2021. Pendimethalin (Compound)

New Jersey Department of Health. 2017. Pendimethalin: Hazardous Substance Fact Sheet.

Beyond Pesticides/NCAMP 2007. Factsheet. Pendimethalin

ON HVAR 2021 Pendimethalin identified in a dust sample taken on June 22nd from a house near vineyards in Svirče

Compiled by Vivian Grisogono MA(Oxon). Information updated 5th October 2021.

Please note: the above information is as complete and accurate as possible, and has taken several years to piece together. If you are aware of inaccuracies or further information which would be relevant to this list, please let us know at This email address is being protected from spambots. You need JavaScript enabled to view it.

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Nature Watch

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About Animals

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Mosquitoes, holiday planning

Category: Forum items

A worried parent asks Eco Hvar about mosquitoes on Hvar. Is there cause for concern?

Mosquitoes and more

Category: Forum items

An Irish family complain to Eco Hvar about the prevalence of mosquitoes during their holiday in Vitarnja.

A learning curve

Category: Forum items

A post on the Eco Hvar Facebook page led to an unexpected response. Eco Hvar learned a lot!

Dragonflies, info request

Category: Forum items

Can anyone help with information about dragonflies on Hvar?

Kingfishers

Category: Forum items

A question about kingfisher behaviours following a sighting in Zavala (Stari Grad) in September 2015.

Hvar's birds declining?

Category: Forum items

Are Hvar's bird numbers dwindling?

Leishmaniasis precautions

Category: Forum items

An inquiry from the UK about leishmaniasis protection measures.

Glyphosate comment

Category: Forum items

An encouraging observation from the United Kingdom:

Help for a 'stray' cat

Category: Forum items

My friend and I visited Hvar over the weekend. During our stay we met a street cat that we grew very attached of each other.

Mosquitoes, worst ever

Category: Forum items

Despite the local authorities' attempts to control mosquitoes with pesticides, many have complained that the mosquitoes on the island are more virulent than ever.

Olive oil producers

Category: Forum items

Query: It was a pleasant surprise to come across your article regarding olive oil making in Dalmatia. Me and my husband have taken it up as a serious hobby to be involved in the olive oil process in m...

Feeding cats in Brela

Category: Forum items

I am staying at the Hotel Berulia in Brela and have been feeding a mother,father and five kittens about (10 weeks old). Do they get rid of the kittens in the winter when there are no guests?

Stray cat in Hvar Town

Category: Forum items

We are currently visiting your lovely island and are staying in the Amfora Hotel. Since our arrival we have fallen in love with a beautiful stray young cat.

Stray dog in Hvar Town

Category: Forum items

Hello I was staying in Hvar Town for 5 days last week in June 14 and we tried our best to care for the kittens, cats we have seen as they were so very skinny. What is keeping me awake at night back in...

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Notices

Poisons: Be aware!

Donations

Donations can be made in kunas or foreign currencies such as euros, pounds, dollars and Swiss francs. Please let us know when you have made a donation, especially if you require an official receipt, as the bank does not always identify donors. All donations, however small, are very welcome.

ECO HVAR BANK DETAILS

Privredna Banka Zagreb d.d.

Poslovnica 220 Pjaca, Pjaca 1

21465 Jelsa, Croatia

IBAN: HR37 2340 0091 1106 0678 6 (Account number)

SWIFT CODE: PBZGHR2X

Account name: ECO HVAR

Account address: Pitve 93, 21465 Jelsa, Croatia

If the payment slip has a box for 'further details' or 'further information' you should enter the Charity's OIB: 14009858487, and state 'donation' or 'donacija'.

Pesticides and their adverse effects

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For the Good of All!

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About Animals

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Notices

Poisons: Be aware!

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